Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Because of its high renal clearance, ciprofloxacin (Cipro) i...
| Class:Id | Summation:9794647 |
|---|---|
| _displayName | Because of its high renal clearance, ciprofloxacin (Cipro) i... |
| _timestamp | 2022-09-25 14:51:30 |
| created | [InstanceEdit:9794666] Stephan, Ralf, 2022-07-19 |
| modified | [InstanceEdit:9817609] Stephan, Ralf, 2022-09-25 |
| text | Because of its high renal clearance, ciprofloxacin (Cipro) is probably not reabsorbed by renal tubular cells. In addition to glomerular secretion, Cipro is also secreted contraluminally by tubular cells (reviewed by Sörgel & Kinzig, 1993). The organic anion transporter Slc22a8 (mOAT3) is highly expressed in kidney (Kobayashi et al, 2004). Cipro interacts with Slc22a8 and inhibits Slc22a8-mediated transport of estrone-3-sulfate competitively (VanWert et al, 2008; reviewed in Burckhardt, 2012). |
| (summation) | [Reaction:9794643] Slc22a8 transports Cipro into renal cell [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Because of its high renal clearance, ciprofloxacin (Cipro) i... (9794647)
