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Details on Person Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme

Class:IdLiteratureReference:9794498
_displayNameMolecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme
_timestamp2022-07-12 20:16:51
author[Person:9794506] Manolopoulou, Marika
[Person:2393949] Guo, Qing
[Person:9794500] Malito, Enrico
[Person:9794495] Schilling, Alexander B
[Person:9794510] Tang, Wei-Jen
created[InstanceEdit:9794499] D'Eustachio, Peter, 2022-07-12
journalJ Biol Chem
modified[InstanceEdit:9794517] D'Eustachio, Peter, 2022-07-12
pages14177-88
pubMedIdentifier19321446
titleMolecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme
volume284
year2009
(literatureReference)[BlackBoxEvent:74730] Insulin degradation [Homo sapiens]
[CatalystActivityReference:9794497] endopeptidase activity of IDE, CTSD [endosome lumen] Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme
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