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Details on Person SLCO1A2 transports Cipro(1+) into the cytosol

Class:Id	Reaction:9794270
_displayName	SLCO1A2 transports Cipro(1+) into the cytosol
_doRelease	TRUE
_timestamp	2022-11-09 22:58:03
authored	[InstanceEdit:9794261] Stephan, Ralf, 2022-07-01
catalystActivity	[CatalystActivity:9794405] transmembrane transporter activity of SLCO1A2 [apical plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:70101] cytosol [Compartment:24781] apical plasma membrane
created	[InstanceEdit:9794264] Stephan, Ralf, 2022-07-01
edited	[InstanceEdit:9795211] Stephan, Ralf, 2022-08-01
input	[SimpleEntity:9793566] Cipro(1+) [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:9794269] Oral drug delivery utilizing intestinal OATP transporters [LiteratureReference:9794263] Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells [LiteratureReference:9794265] Identification of influx transporter for the quinolone antibacterial agent levofloxacin
modified	[InstanceEdit:9794402] Stephan, Ralf, 2022-07-05 [InstanceEdit:9795211] Stephan, Ralf, 2022-08-01 [InstanceEdit:9795213] Stephan, Ralf, 2022-08-01 [InstanceEdit:9820564] Matthews, Lisa, 2022-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SLCO1A2 transports Cipro(1+) into the cytosol
output	[SimpleEntity:9793625] Cipro [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[BlackBoxEvent:9793564] Cipro HCl dissolves [Homo sapiens]
releaseDate	2022-12-07
reviewed	[InstanceEdit:9820563] Thorn, Caroline F, 2022-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9794277] R-HSA-9794270.2
summation	[Summation:9794268] Transport protein SLCO1A2 (organic anion transporting polype...
(hasEvent)	[Pathway:9793528] Ciprofloxacin ADME [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9794414] Basolateral transport of Cipro to extracellular space [Homo sapiens]
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