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Details on Person Expression of Dll1 in paraxial mesoderm

Class:Id	BlackBoxEvent:9793915
_displayName	Expression of Dll1 in paraxial mesoderm
_doRelease	TRUE
_timestamp	2023-08-23 18:19:03
authored	[InstanceEdit:9793929] May, Bruce, 2022-06-19
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9793807] May, Bruce, 2022-06-24
edited	[InstanceEdit:9793929] May, Bruce, 2022-06-19
input	[EntityWithAccessionedSequence:9023389] Dll1 gene [nucleoplasm] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:9793865] Dll1 is a downstream target of Tbx6 in the paraxial mesoderm [LiteratureReference:9793871] LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis [LiteratureReference:9793918] Dynamic Delta-like1 expression in presomitic mesoderm cells during somite segmentation [LiteratureReference:9793879] The mouse rib-vertebrae mutation disrupts anterior-posterior somite patterning and genetically interacts with a Delta1 null allele [LiteratureReference:9793834] WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos [LiteratureReference:9793816] Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints [LiteratureReference:9793877] Spatiotemporal oscillations of Notch1, Dll1 and NICD are coordinated across the mouse PSM [LiteratureReference:9793902] Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta [LiteratureReference:9793919] Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm [LiteratureReference:9794037] Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation
modified	[InstanceEdit:9794076] May, Bruce, 2022-06-27 [InstanceEdit:9819299] May, Bruce, 2022-11-02 [InstanceEdit:9820534] May, Bruce, 2022-11-09 [InstanceEdit:9824335] May, Bruce, 2023-01-18 [InstanceEdit:9825334] May, Bruce, 2023-01-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9832067] May, Bruce, 2023-03-28 [InstanceEdit:9842213] May, Bruce, 2023-08-23
name	Expression of Dll1 in paraxial mesoderm
output	[EntityWithAccessionedSequence:2032251] Dll1 [plasma membrane] [Mus musculus]
regulatedBy	[PositiveGeneExpressionRegulation:9793408] Positive gene expression regulation by 'Tbxt [nucleoplasm]' [PositiveGeneExpressionRegulation:9793880] Positive gene expression regulation by 'Tbx6:Lef1:Ctnnb1:Dll1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9824329] Positive gene expression regulation by 'Tbx6:Lef1:Ctnnb1:Dll1 gene [nucleoplasm]' Dll1 is a downstream target of Tbx6 in the paraxial mesoderm [RegulationReference:9825322] Positive gene expression regulation by 'Tbxt [nucleoplasm]' WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos
releaseDate	2022-12-07
requiredInputComponent	[EntityWithAccessionedSequence:206283] Psen1(1-298) [plasma membrane] [Mus musculus]
reviewed	[InstanceEdit:9820530] Yamaguchi, Terry P, 2022-11-09 [InstanceEdit:9820524] Chalamalasetty, Ravindra B, 2022-11-09 [InstanceEdit:9834677] Chalamalasetty, Ravindra B, 2023-05-09 [InstanceEdit:9834682] Yamaguchi, Terry P, 2023-05-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9793937] R-MMU-9793915.4
structureModified	[InstanceEdit:9832067] May, Bruce, 2023-03-28
summation	[Summation:9793867] Delta-like 1 (Dll1) is expressed in paraxial (presomitic) me...
(inferredFrom)	[BlackBoxEvent:9793921] Expression of DLL1 in paraxial mesoderm [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9835734] Update Tracker - [BlackBoxEvent:9793915] Expression of Dll1 in paraxial mesoderm - v85:[add_removeInput]
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