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Details on Person Diagram of Ciprofloxacin ADME

Class:IdPathwayDiagram:9793574
_displayNameDiagram of Ciprofloxacin ADME
_timestamp2022-09-25 15:03:30
created[InstanceEdit:9793575] Stephan, Ralf, 2022-06-21
height1420
modified[InstanceEdit:9793626] Stephan, Ralf, 2022-06-22
[InstanceEdit:9794138] Stephan, Ralf, 2022-06-27
[InstanceEdit:9794264] Stephan, Ralf, 2022-07-01
[InstanceEdit:9794348] Stephan, Ralf, 2022-07-04
[InstanceEdit:9794398] Stephan, Ralf, 2022-07-05
[InstanceEdit:9794399] Stephan, Ralf, 2022-07-05
[InstanceEdit:9794410] Stephan, Ralf, 2022-07-06
[InstanceEdit:9794413] Stephan, Ralf, 2022-07-06
[InstanceEdit:9794442] Stephan, Ralf, 2022-07-07
[InstanceEdit:9794447] Stephan, Ralf, 2022-07-07
[InstanceEdit:9794474] Stephan, Ralf, 2022-07-09
[InstanceEdit:9794529] Stephan, Ralf, 2022-07-13
[InstanceEdit:9794550] Stephan, Ralf, 2022-07-15
[InstanceEdit:9794571] Stephan, Ralf, 2022-07-15
[InstanceEdit:9794574] Stephan, Ralf, 2022-07-18
[InstanceEdit:9794829] Stephan, Ralf, 2022-07-21
[InstanceEdit:9794985] Stephan, Ralf, 2022-07-25
[InstanceEdit:9795132] Stephan, Ralf, 2022-07-28
[InstanceEdit:9795141] Stephan, Ralf, 2022-07-28
[InstanceEdit:9795142] Stephan, Ralf, 2022-07-28
[InstanceEdit:9795143] Stephan, Ralf, 2022-07-28
[InstanceEdit:9795144] Stephan, Ralf, 2022-07-29
[InstanceEdit:9795151] Stephan, Ralf, 2022-07-29
[InstanceEdit:9795152] Stephan, Ralf, 2022-07-29
[InstanceEdit:9795208] Stephan, Ralf, 2022-08-01
[InstanceEdit:9795210] Stephan, Ralf, 2022-08-01
[InstanceEdit:9817610] Stephan, Ralf, 2022-09-25
[InstanceEdit:9817611] Stephan, Ralf, 2022-09-25
representedPathway[Pathway:9793528] Ciprofloxacin ADME [Homo sapiens]
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</org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="211" reactomeId="24781" position="440 778" bounds="388 607 105 343" textPosition="390 864" bgColor="250 240 240" lineColor="255 153 102"> <Components> <Component id="217" /> <Component id="181" /> <Component id="158" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="217" reactomeId="9794403" position="437 669" bounds="378 656 118 26" textPosition="407 658"> <Properties> <displayName>SLCO1A2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="218" reactomeId="9794404" position="1733 1125" bounds="1682 1115 103 20" textPosition="1686 1113" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableCompartment id="237" reactomeId="24778" position="671 780" bounds="618 614 106 333" textPosition="622 622" bgColor="250 240 240" lineColor="255 153 102"> <Components> <Component id="236" /> </Components> 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</Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="543" reactomeId="24778" position="1418 229" bounds="1357 72 123 314" textPosition="1354 76" bgColor="250 240 240" lineColor="255 153 102"> <Components> <Component id="547" /> <Component id="629" /> <Component id="546" /> <Component id="628" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="544" reactomeId="24781" position="1704 225" bounds="1650 65 108 320" textPosition="1655 320" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>apical plasma membrane</displayName> </Properties> <Components> <Component id="596" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="547" reactomeId="9794526" position="1418 224" bounds="1352 212 132 24" textPosition="1389 213"> <Properties> <displayName>SLC22A1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="549" reactomeId="9793625" position="1570 179" bounds="1548 164 45 31" textPosition="1552 168" /> <org.gk.render.Note id="551" position="452 583" bounds="395 570 115 26" textPosition="413 572"> <Properties> <displayName>Stomach cell</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.Note> <org.gk.render.Note id="552" position="1411 1049" bounds="1388 1038 46 23" textPosition="1391 1038"> <Properties> <displayName>GI cell</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.Note> <org.gk.render.Note id="553" position="1409 21" bounds="1370 10 78 22" textPosition="1379 10"> <Properties> <displayName>Renal cell</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.Note> <org.gk.render.RenderableChemical id="591" reactomeId="9794119" position="1875 177" bounds="1853 162 45 31" textPosition="1857 166" /> <org.gk.render.RenderableCompartment id="598" reactomeId="70101" position="1588 742" bounds="1304 482 569 521" textPosition="1408 493" bgColor="250 240 240" lineColor="255 153 102" insets="1400 490 375 505"> <Components> <Component id="599" /> <Component id="604" /> <Component id="603" /> <Component id="605" /> <Component id="609" /> <Component id="611" /> <Component id="1179" /> <Component id="1180" /> <Component id="1194" /> <Component id="1195" /> <Component id="1204" /> <Component id="1207" /> <Component id="1206" /> <Component id="1205" /> <Component id="1209" /> <Component id="186" /> <Component id="186" /> <Component id="600" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="599" reactomeId="24781" position="1822 741" bounds="1778 494 89 495" textPosition="1781 907" bgColor="250 240 240" lineColor="255 153 102"> <Components> <Component id="614" /> <Component id="602" /> <Component id="1239" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="600" reactomeId="24778" position="1353 754" bounds="1305 519 96 471" textPosition="1308 523" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>basolateral plasma membrane</displayName> </Properties> <Components> <Component id="1249" /> <Component id="1259" /> <Component id="1257" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="603" reactomeId="113592" position="1719 774" bounds="1699 759 40 31" textPosition="1703 763" /> <org.gk.render.RenderableChemical id="604" reactomeId="29356" position="1742 809" bounds="1720 794 45 31" textPosition="1726 798"> <Properties> <displayName>H2O</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="605" reactomeId="29370" position="1684 709" bounds="1663 693 43 33" textPosition="1668 698"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="607" reactomeId="9794119" position="2025 746" bounds="2003 731 45 31" textPosition="2007 735" /> <org.gk.render.RenderableChemical id="609" reactomeId="1524165" position="1735 696" bounds="1722 681 27 31" textPosition="1726 685" /> <org.gk.render.RenderableChemical id="611" reactomeId="9793625" position="1614 744" bounds="1592 729 45 31" textPosition="1596 733" /> <org.gk.render.RenderableComplex id="614" reactomeId="9794404" position="1825 696" bounds="1777 685 97 23" textPosition="1778 686" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ABCG2 tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="629" reactomeId="9794651" position="1417 339" bounds="1355 328 125 22" textPosition="1388 328"> <Properties> <displayName>SLC22A8</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="1180" reactomeId="9794837" position="1469 921" bounds="1434 906 70 31" textPosition="1439 910" /> <org.gk.render.RenderableChemical id="1194" reactomeId="29368" position="1531 800" bounds="1515 785 32 31" textPosition="1519 789"> <Properties> <displayName>O2</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1195" reactomeId="29356" position="1590 937" bounds="1570 922 41 31" textPosition="1574 926" /> <org.gk.render.RenderableChemical id="1205" reactomeId="158471" position="1488 619" bounds="1465 600 46 39" textPosition="1468 608"> <Properties> <displayName>PAPS</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1206" reactomeId="158466" position="1603 541" bounds="1584 524 39 35" textPosition="1587 530"> <Properties> <displayName>PAP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1207" reactomeId="9795138" position="1711 564" bounds="1684 545 54 39" textPosition="1692 546"> <Properties> <displayName>sulfo-Cipro</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1209" reactomeId="29368" position="1522 702" bounds="1506 687 32 31" textPosition="1510 691" /> <org.gk.render.RenderableChemical id="1217" reactomeId="9794119" position="1176 740" bounds="1154 725 45 31" textPosition="1158 729" /> <org.gk.render.Note id="1226" position="1347 464" bounds="1312 456 71 17" textPosition="1313 454"> <Properties> <displayName>hepatic cell</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.Note> <org.gk.render.RenderableChemical id="1240" reactomeId="9795145" position="2022 562" bounds="1992 538 60 48" textPosition="2003 544" /> <org.gk.render.RenderableChemical id="1250" reactomeId="9795154" position="1015 917" bounds="974 898 82 39" textPosition="985 906"> <Properties> <displayName>oxo-Cipro</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="1259" reactomeId="9794526" position="1356 822" bounds="1299 811 114 23" textPosition="1327 811" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="149" reactomeId="9793564" points="134 745, 198 744, 197 744" position="198 744" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="150" /> </Inputs> <Outputs> <Output id="151" points="213 705" /> <Output id="152" points="284 744" /> </Outputs> <Properties> <displayName>Cipro HCl dissolves</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="158" reactomeId="9793628" points="343 760, 442 822, 441 820" position="442 822" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="152" /> </Inputs> <Outputs> <Output id="159" points="542 754" /> <Output id="160" points="553 691" /> </Outputs> <Properties> <displayName>Cipro is imported by organic cation transporters</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="161" reactomeId="9794120" points="1730 1206, 1735 1210, 1731 1206" position="1735 1210" lineWidth="1.0"> <Inputs> <Input id="162" points="1575 1330" /> <Input id="163" points="1636 1326" /> <Input id="169" points="1609 1207" /> </Inputs> <Outputs> <Output id="164" points="1618 1130" /> <Output id="165" points="1959 1205" /> <Output id="166" points="1662 1131" /> </Outputs> <Catalysts> <Catalyst id="218" points="1733 1138" /> </Catalysts> <Properties> <displayName>ABCG2 transports Cipro from intestinal cell to extracellular space</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="181" reactomeId="9794270" points="343 744, 436 744, 436 744" position="436 744" lineWidth="1.0"> <Inputs> <Input id="152" /> </Inputs> <Outputs> <Output id="160" points="548 680" /> <Output id="159" points="542 740" /> </Outputs> <Catalysts> <Catalyst id="217" points="436 685" /> </Catalysts> <Properties> <displayName>SLCO1A2 transports Cipro(1+) into the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="186" reactomeId="9794352" points="1175 759, 1173 1208, 1420 1208, 1558 1208" position="1420 1208" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="1217" /> </Inputs> <Outputs> <Output id="169" /> </Outputs> <Properties> <displayName>Basolateral transport of Cipro into intestinal cell</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="236" reactomeId="9794414" points="593 739, 687 738, 767 737" position="687 738" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="159" /> </Inputs> <Outputs> <Output id="240" /> </Outputs> <Properties> <displayName>Basolateral transport of Cipro to extracellular space</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="244" reactomeId="9794444" points="860 737, 860 738, 917 737" position="860 738" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="245" points="945 795" /> <Input id="240" points="818 737" /> </Inputs> <Outputs> <Output id="246" /> </Outputs> <Properties> <displayName>ALB binds Cipro</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="539" reactomeId="9794475" points="990 737, 1057 739, 1060 741" position="1057 739" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="246" /> </Inputs> <Outputs> <Output id="245" points="983 795" /> <Output id="1217" points="1151 740" /> </Outputs> <Properties> <displayName>Cipro:ALB dissociates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="546" reactomeId="9794523" points="1175 722, 1166 181, 1419 179, 1545 179" position="1419 179" lineWidth="1.0"> <Inputs> <Input id="1217" /> </Inputs> <Outputs> <Output id="549" /> </Outputs> <Catalysts> <Catalyst id="547" points="1418 209" /> </Catalysts> <Properties> <displayName>SLC22A1 transports Cipro into renal cell</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="596" reactomeId="9794569" points="1596 179, 1703 181, 1850 177" position="1703 181" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="549" /> </Inputs> <Outputs> <Output id="591" /> </Outputs> <Properties> <displayName>Apical transport of Cipro to extracellular space</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="602" reactomeId="9794572" points="1825 747, 1822 744, 1825 747" position="1822 744" lineWidth="1.0"> <Inputs> <Input id="603" points="1742 768" /> <Input id="604" points="1762 791" /> <Input id="611" points="1640 744" /> </Inputs> <Outputs> <Output id="605" points="1709 714" /> <Output id="607" points="2000 746" /> <Output id="609" points="1752 703" /> </Outputs> <Catalysts> <Catalyst id="614" points="1824 711" /> </Catalysts> <Properties> <displayName>ABCG2 transports Cipro from hepatic cell to extracellular space</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="628" reactomeId="9794830" points="1176 722, 1189 300, 1417 298, 1550 198" position="1417 298" lineWidth="1.0"> <Inputs> <Input id="1217" /> </Inputs> <Outputs> <Output id="549" /> </Outputs> <Catalysts> <Catalyst id="629" points="1417 325" /> </Catalysts> <Properties> <displayName>SLC22A8 transports Cipro into renal cell</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1179" reactomeId="9794840" points="1580 834, 1563 863, 1544 898" position="1563 863" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="1194" points="1550 811" /> <Input id="611" points="1608 763" /> </Inputs> <Outputs> <Output id="1195" points="1571 919" /> <Output id="1180" points="1507 910" /> </Outputs> <Properties> <displayName>Cipro is oxidized to oxo-Cipro</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1204" reactomeId="9795134" points="1579 658, 1608 638, 1633 616" position="1608 638" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="1205" stoichiometry="2" points="1514 628" /> <Input id="611" stoichiometry="2" points="1607 726" /> <Input id="1209" points="1541 689" /> </Inputs> <Outputs> <Output id="1206" stoichiometry="2" points="1610 562" /> <Output id="1207" stoichiometry="2" points="1681 582" /> </Outputs> <Properties> <displayName>Cipro is sulfonated to sulfo-Cipro</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1239" reactomeId="9795147" points="1741 564, 1829 564, 1989 562" position="1829 564" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="1207" /> </Inputs> <Outputs> <Output id="1240" /> </Outputs> <Properties> <displayName>Apical excretion of sulfo-Cipro</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1249" reactomeId="9795153" points="1431 921, 1349 921, 1059 917" position="1349 921" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="1180" /> </Inputs> <Outputs> <Output id="1250" /> </Outputs> <Properties> <displayName>Basolateral excretion of oxo-Cipro</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1257" reactomeId="9795207" points="1202 740, 1357 741, 1589 743" position="1357 741" lineWidth="1.0"> <Inputs> <Input id="1217" /> </Inputs> <Outputs> <Output id="611" /> </Outputs> <Catalysts> <Catalyst id="1259" points="1356 808" /> </Catalysts> <Properties> <displayName>SLC22A1 transports Cipro into hepatic cell</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Ciprofloxacin ADME (9793574)