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Details on Person PRKN polyubiquitinates RIPK3

Class:IdBlackBoxEvent:9793485
_displayNamePRKN polyubiquitinates RIPK3
_doReleaseTRUE
_timestamp2022-11-07 22:36:16
authored[InstanceEdit:9793470] Shamovsky, Veronica, 2022-06-15
catalystActivity[CatalystActivity:9794187] ubiquitin-protein transferase activity of RIPK3:p-S9-PRKN:Ub:UBE2L3 [cytosol]
catalystActivityReference[CatalystActivityReference:9794188] ubiquitin-protein transferase activity of RIPK3:p-S9-PRKN:Ub:UBE2L3 [cytosol] The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome
compartment[Compartment:70101] cytosol
created[InstanceEdit:9793470] Shamovsky, Veronica, 2022-06-15
edited[InstanceEdit:9819392] Shamovsky, Veronica, 2022-11-04
input[Complex:9793473] RIPK3:p-S9-PRKN:Ub:UBE2L3 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9793492] The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome
modified[InstanceEdit:9794178] Shamovsky, Veronica, 2022-06-27
[InstanceEdit:9794186] Shamovsky, Veronica, 2022-06-27
[InstanceEdit:9819049] Shamovsky, Veronica, 2022-10-31
[InstanceEdit:9820396] Shamovsky, Veronica, 2022-11-07
[InstanceEdit:9820477] Shamovsky, Veronica, 2022-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePRKN polyubiquitinates RIPK3
output[EntityWithAccessionedSequence:8864201] Ub-C86-UBE2L3 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9793481] p-S9-PRKN [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9794180] K33polyUb-K197,302,364-RIPK3 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2022-12-07
reviewed[InstanceEdit:9820382] Murphy, James M, 2022-11-07
[InstanceEdit:9794397] D'Eustachio, Peter, 2022-07-05
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9793495] R-HSA-9793485.2
summation[Summation:9794179] E3 ubiquitin-protein ligase parkin (PRKN, also known as PARK...
(hasEvent)[Pathway:5675482] Regulation of necroptotic cell death [Homo sapiens]
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No pathways have been reviewed or authored by PRKN polyubiquitinates RIPK3 (9793485)