Query author contributions in Reactome
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Details on Person Tbx6 is expressed in the primitive streak and then expressio...
| Class:Id | Summation:9793422 |
|---|---|
| _displayName | Tbx6 is expressed in the primitive streak and then expressio... |
| _timestamp | 2022-11-09 05:49:20 |
| created | [InstanceEdit:9793419] May, Bruce, 2022-06-12 |
| modified | [InstanceEdit:9794076] May, Bruce, 2022-06-27 [InstanceEdit:9794212] May, Bruce, 2022-06-28 [InstanceEdit:9794518] May, Bruce, 2022-07-13 [InstanceEdit:9820550] May, Bruce, 2022-11-09 |
| text | Tbx6 is expressed in the primitive streak and then expression continues in the paraxial mesoderm (Chapman et al. 1996). Notch signaling acting through Rbpj activates expression of Tbx6 in paraxial mesoderm (White et al. 2005). Wnt signaling (Dunty et al. 2008, Nowotschin et al. 2012) and Fgf signaling (Ciruna and Rossant 2001) also directly or indirectly activate expression of Tbx6 in paraxial mesoderm. Tbxt is not required for initial activation of Tbx6 expression, but Tbxt is required for maintenance of Tbx6 expression (Chapman et al. 1996). Mesogenin1 (Msgn1), which is itself activated by Tbx6, activates Tbx6 in a reinforcing loop (Chalamalasetty et al. 2014). |
| (summation) | [BlackBoxEvent:9793405] Expression of Tbx6 in paraxial mesoderm [Mus musculus] |
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No pathways have been reviewed or authored by Tbx6 is expressed in the primitive streak and then expressio... (9793422)
