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Details on Person proHPSE:SDC1 is delivered to lysosomes

Class:Id	BlackBoxEvent:9792581
_displayName	proHPSE:SDC1 is delivered to lysosomes
_doRelease	TRUE
_timestamp	2025-05-21 08:29:10
authored	[InstanceEdit:9792562] D'Eustachio, Peter, 2022-05-26
compartment	[Compartment:161320] lysosomal lumen [Compartment:876] plasma membrane
created	[InstanceEdit:9792575] D'Eustachio, Peter, 2022-05-26
edited	[InstanceEdit:9948077] Stephan, Ralf, 2025-05-15
goBiologicalProcess	[GO_BiologicalProcess:1221299] clathrin-dependent endocytosis
input	[Complex:9792578] proHPSE:SDC1 [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9945059] Stephan, Ralf, 2025-04-10
isChimeric	FALSE
literatureReference	[LiteratureReference:9792572] Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and α-actinin
modified	[InstanceEdit:9792592] D'Eustachio, Peter, 2022-05-26 [InstanceEdit:9945060] Stephan, Ralf, 2025-04-10 [InstanceEdit:9948075] Stephan, Ralf, 2025-05-15 [InstanceEdit:9948472] Stephan, Ralf, 2025-05-21
name	proHPSE:SDC1 is delivered to lysosomes
output	[Complex:9792577] proHPSE:SDC1 [lysosomal lumen] [Homo sapiens]
precedingEvent	[Reaction:9792569] proHPSE binds SDC1 [Homo sapiens] [BlackBoxEvent:2024108] Some HSPGs are secreted to the plasma membrane [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-06-18
reviewed	[InstanceEdit:9948076] D'Eustachio, Peter, 2025-05-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9792588] R-HSA-9792581.1
summation	[Summation:9792574] The proHPSE:syndecan1 complex associated with the plasma mem...
(hasEvent)	[Pathway:2024096] HS-GAG degradation [Homo sapiens]
(precedingEvent)	[Reaction:9941078] proHPSE dissociates from HS(6)-SDC1 [Homo sapiens]
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No pathways have been reviewed or authored by proHPSE:SDC1 is delivered to lysosomes (9792581)