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Details on Person UniProt:Q99PJ1 Pcdh15
| Class:Id | ReferenceGeneProduct:97837 |
|---|---|
| _chainChangeLog | signal peptide:1-26 added on Fri February 6 2015;chain:27-1943 added on Fri February 6 2015 |
| _displayName | UniProt:Q99PJ1 Pcdh15 |
| _timestamp | 2024-08-09 18:36:24 |
| chain | signal peptide:1-26 chain:27-1943 |
| checksum | 6FD6836082655855 |
| comment | FUNCTION Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function.SUBUNIT Antiparallel heterodimer with CDH23 (PubMed:17805295, PubMed:23135401). Found in a complex with TMIE and LHFPL5 (PubMed:25467981). Interacts with LHFPL5/TMHS; this interaction is required for efficient localization to hair bundles (PubMed:23217710). Interacts with MYO7A (PubMed:16481439). Interacts with USH1G; this interaction may recruit USH1G to the plasma membrane (PubMed:21436032). Interacts with TOMT (PubMed:28504928). Isoforms CD1 and CD3 interact with TMC1 (via N-terminus) and TMC2 (via N-terminus) (PubMed:25114259). Interacts with PIEZO1 (PubMed:38228630).INTERACTION Efficient localization to the plasma membrane requires the presence of LHFPL5.SUBCELLULAR LOCATION Expressed in brain and sensory epithelium of the developing inner ear. Expressed in the retina, in the photoreceptor inner segments, the outer plexiform layer, the inner nuclei layer and the ganglion cell layer and, more diffusely in the inner plexiform layer (at protein level). Not detected in the retinal pigment epithelium (at protein level). Expressed in the spleen, dorsal root ganglion, dorsal aspect of neural tube, floor plate and ependymal cells adjacent to the neural canal.DEVELOPMENTAL STAGE Highest level of expression is detected at embryonic day 16. Alternative splicing isoforms have different spatiotemporal expression patterns. In cochlear cultures at the equivalent of postnatal day 3, isoforms belonging to the CD1 (isoforms 1 through 9) and CD3 (isoforms 18 through 20) groups are highly expressed in hair bundles in the basal coils and moderately in those in the middle of the apical coil; they are hardly detectable in those at the apical end of the apical coil (at protein level). At the base of the cultured cochlea, in the more mature hair bundles, CD3 group isoforms are restricted to the tips of the shorter stereocilia in both inner and outer hair cells. By contrast, at the same stage, isoforms belonging to the CD2 group (isoforms 10 through 17) are highly expressed in hair bundles in the apex of the cochlea and, at lower levels, in those in the middle of the apical coil; they are hardly detectable at the base of the cochlea (at protein level). In mature hair bundles, CD1 group isoforms are distributed fairly evenly along most of the length of the stereocilia on auditory hair cells, whereas they are concentrated toward the upper third of the hair bundle in vestibular hair cells. In both the auditory and the vestibular organs, these isoforms are excluded from a region at the very tip of each stereocilium (at protein level). In contrast, CD2 group isoforms are undetectable in adult cochlear hair cells (at protein level). These isoforms are expressed in the entire hair bundle of the immature cells in the sensory epithelium of the early postnatal vestibule and only in the kinocilium in the more mature hair bundles (at protein level). CD3 group isoforms are detected in immature vestibular hair bundles, concentrated toward the tip of each stereocilium, as early as 15.5 dpc. They also localize to the tips of the shorter stereocilia in the mature vestibular hair bundles and are not detected at the tips of the stereocilia in the tallest row (at protein level).DOMAIN Cadherin repeats 1 and 2 mediate calcium-dependent heterophilic interaction with CDH23.DOMAIN Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.DISEASE Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.MISCELLANEOUS Produced by aberrant splicing sites.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: Protocadherin-15 |
| geneName | Pcdh15 |
| identifier | Q99PJ1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Calcium Cell adhesion Cell membrane Deafness Direct protein sequencing Disulfide bond Glycoprotein Hearing Membrane Reference proteome Repeat Secreted Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5083144] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | Pcdh15 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PCD15_MOUSE D6RCH0 E9Q7D7 E9Q7R1 E9Q7R2 F6KJX4 F6KKG6 F6R5Z7 F6RBV2 F6U3Q6 F6UPC9 F6VPR3 F6WUN7 F6X715 F6XPA1 F6Y0A5 F6YP25 F6YZQ9 F7ASH0 F7CIN1 F7D5J8 F7DFU0 F8VQ61 H3BKS0 Q0ZM15 Q0ZM16 Q0ZM18 Q0ZM19 Q0ZM20 Q0ZM21 Q0ZM22 Q0ZM23 Q0ZM24 Q0ZM25 Q0ZM26 Q0ZM27 Q0ZM28 Q0ZM29 Q0ZM30 Q0ZM31 Q0ZM32 Q0ZM33 Q0ZM34 Q0ZM35 Q0ZM37 Q2VQG7 Q3URZ1 Q3UTS7 |
| sequenceLength | 1943 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:8969333] UniProt:Q99PJ1-1 Pcdh15 [Mus musculus] [ReferenceIsoform:8969334] UniProt:Q99PJ1-10 Pcdh15 [Mus musculus] [ReferenceIsoform:8969335] UniProt:Q99PJ1-11 Pcdh15 [Mus musculus] [ReferenceIsoform:8969336] UniProt:Q99PJ1-12 Pcdh15 [Mus musculus] [ReferenceIsoform:8969337] UniProt:Q99PJ1-13 Pcdh15 [Mus musculus] [ReferenceIsoform:8969338] UniProt:Q99PJ1-14 Pcdh15 [Mus musculus] [ReferenceIsoform:8969339] UniProt:Q99PJ1-15 Pcdh15 [Mus musculus] [ReferenceIsoform:8969340] UniProt:Q99PJ1-16 Pcdh15 [Mus musculus] [ReferenceIsoform:8969341] UniProt:Q99PJ1-17 Pcdh15 [Mus musculus] [ReferenceIsoform:8969342] UniProt:Q99PJ1-18 Pcdh15 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9658868] Pcdh15 [plasma membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q99PJ1 Pcdh15 (97837)
