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Details on Person UniProt:P47239 Pax7

Class:Id	ReferenceGeneProduct:97813
_chainChangeLog	chain:1-503 added on Fri February 6 2015
_displayName	UniProt:P47239 Pax7
_timestamp	2024-08-09 19:04:26
chain	chain:1-503
checksum	8ECC952C5C2FCA27
comment	FUNCTION Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration.SUBUNIT Can bind to DNA as a heterodimer with PAX3. Interacts with DAXX (By similarity). Interacts with PAXBP1; the interaction links PAX7 to a WDR5-containing histone methyltransferase complex (PubMed:22862948).SUBCELLULAR LOCATION Expressed specifically during the development of the nervous and muscular system.PTM Acetylation at Lys-105 and Lys-139 by KAT8 is required for high-level transcription factor activity (PubMed:34059674). Deacetylated by SIRT2 (PubMed:34059674).SIMILARITY Belongs to the paired homeobox family.
description	recommendedName: fullName evidence="10"Paired box protein Pax-7
geneName	Pax7 Pax-7
identifier	P47239
isSequenceChanged	FALSE
keyword	Acetylation Developmental protein DNA-binding Homeobox Myogenesis Nucleus Paired box Reference proteome Transcription Transcription regulation
modified	[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09
name	Pax7
referenceDatabase	[ReferenceDatabase:2] UniProt
secondaryIdentifier	PAX7_MOUSE Q9ES16
sequenceLength	503
species	[Species:48892] Mus musculus
(referenceEntity)	[EntityWithAccessionedSequence:9678023] Pax7 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9678037] Me2aR10,R13,R22,R37-Pax7 [nucleoplasm] [Mus musculus]
(referenceSequence)	[ModifiedResidue:9678034] asymmetric dimethyl-L-arginine at 13 [ModifiedResidue:9678036] asymmetric dimethyl-L-arginine at 10 [ModifiedResidue:9678040] asymmetric dimethyl-L-arginine at 37 [ModifiedResidue:9678042] asymmetric dimethyl-L-arginine at 22
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No pathways have been reviewed or authored by UniProt:P47239 Pax7 (97813)