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Details on Person Displacement of C2a/Bb by CR1

Class:Id	Reaction:977629
_displayName	Displacement of C2a/Bb by CR1
_doRelease	TRUE
_timestamp	2012-03-01 11:22:52
authored	[InstanceEdit:981647] Jupe, S, 2010-10-26
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:977612] Jupe, S, 2010-10-20
edited	[InstanceEdit:983442] Jupe, S, 2010-11-01
input	[DefinedSet:981676] CR1:C3bBb, C4bC2a complexes [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:977358] Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane [LiteratureReference:981672] Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb [LiteratureReference:1006147] Decay accelerating activity of complement receptor type 1 (CD35). Two active sites are required for dissociating C5 convertases
modified	[InstanceEdit:981504] Jupe, S, 2010-10-21 [InstanceEdit:981647] Jupe, S, 2010-10-26 [InstanceEdit:998152] Jupe, S, 2010-11-09 [InstanceEdit:1006170] Jupe, S, 2010-11-10 [InstanceEdit:1022141] Jupe, S, 2010-11-17 [InstanceEdit:1096479] Jupe, S, 2010-11-30 [InstanceEdit:1168688] Jupe, S, 2011-01-06 [InstanceEdit:2109565] Jupe, S, 2012-02-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Displacement of C2a/Bb by CR1
output	[EntityWithAccessionedSequence:166780] C2a [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:182453] CFB(260-764) [extracellular region] [Homo sapiens] [Complex:981635] CR1:C3b [plasma membrane] [Homo sapiens] [Complex:981675] CR1:C4b [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:977375] CR1 binds C3bBb/C4bC2a [Homo sapiens] [Reaction:166795] Formation of Classical C3 convertase (C4b:C2a complex) [Homo sapiens] [Reaction:173745] Factor D cleaves C3(H2O)-bound Factor B [Homo sapiens] [Reaction:183122] Factor D cleaves C3b-bound Factor B [Homo sapiens]
releaseDate	2012-03-13
reviewed	[InstanceEdit:2109568] Bradley, DT, 2012-02-13 [InstanceEdit:2109566] Fraczek, LA, 2012-02-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2158122] R-HSA-977629.2
summation	[Summation:981671] Complement Receptor 1 (CR1) displaces the activated enzyme c...
(hasEvent)	[Pathway:977606] Regulation of Complement cascade [Homo sapiens]
(inferredFrom)	[Reaction:2530591] CREG (CR1L) causes dissociation of C3 convertases [Gallus gallus]
(precedingEvent)	[Reaction:977602] Complement factor I binds to MCP, CR1:C4b, C3b [Homo sapiens]
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