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Details on Person Active IKBKB phosphorylates NF-kappa-B inhibitor

Class:Id	Reaction:9773803
_displayName	Active IKBKB phosphorylates NF-kappa-B inhibitor
_doRelease	TRUE
_timestamp	2022-05-18 13:21:35
authored	[InstanceEdit:9758273] Shamovsky, Veronica, 2021-11-09
catalystActivity	[CatalystActivity:9773806] protein serine/threonine kinase activity of CHUK:p-S177,S181-IKBKB:IKBKG [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9773804] Shamovsky, Veronica, 2022-05-10
edited	[InstanceEdit:9773904] Shamovsky, Veronica, 2022-05-10
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:168130] NFkB inhibitor:NFkB complex [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:177888] Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex [LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases [LiteratureReference:9630958] Double phosphorylation-induced structural changes in the signal-receiving domain of IκBα in complex with NF-κB
modified	[InstanceEdit:9773813] Shamovsky, Veronica, 2022-05-10 [InstanceEdit:9774033] Shamovsky, Veronica, 2022-05-12 [InstanceEdit:9774121] Shamovsky, Veronica, 2022-05-17 [InstanceEdit:9774130] Matthews, Lisa, 2022-05-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Active IKBKB phosphorylates NF-kappa-B inhibitor
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:168155] NFKB1(1-433), NFKB2(1-454):RELA [cytosol] [Homo sapiens] [DefinedSet:177678] Phospho-NF-kappaB Inhibitor [cytosol] [Homo sapiens]
precedingEvent	[Reaction:168184] Activated TAK1 mediates phosphorylation of the IKK Complex [Homo sapiens] [Reaction:847070] Phosphorylated TAK1 dissociates from the TLR3 receptor complex [Homo sapiens] [BlackBoxEvent:706479] TAK1 is activated [Homo sapiens] [Reaction:936991] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 [Homo sapiens] [Reaction:936951] Activation of TAK1 complex bound to activated TLR4 complex [Homo sapiens] [Reaction:9645442] Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex [Homo sapiens] [Reaction:5609665] CHUK, IKBKB and IKBKG form IKK complex [Homo sapiens] [Reaction:9630923] NF-kappa-B inhibitor binds NF-kappa-B complex [Homo sapiens]
regulatedBy	[NegativeRegulation:8952695] Negative regulation by 'NKIRAS [cytosol]'
regulationReference	[RegulationReference:9641502] Negative regulation by 'NKIRAS [cytosol]' KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes
releaseDate	2022-06-09
reviewed	[InstanceEdit:2023355] D'Eustachio, P, 2011-12-07 [InstanceEdit:9773242] de Martin, R, 2022-05-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9773807] R-HSA-9773803.2
summation	[Summation:9773805] In human, IkBs (NFKBIA, NFKBIB or NFKBIE) are inhibitory pro...
systematicName	CHUK:IKBKB:IKBKG phosphorylates IkBs:NFkB
(hasEvent)	[Pathway:445989] TAK1-dependent IKK and NF-kappa-B activation [Homo sapiens]
(normalReaction)	[FailedReaction:5228811] NFKBIA variant is not phosphorylated within IkBA:NF-kappaB [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9773816] Futile Cycle: Active IKBKB phosphorylates NF-kappa-B inhibitor [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus [Homo sapiens]
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No pathways have been reviewed or authored by Active IKBKB phosphorylates NF-kappa-B inhibitor (9773803)