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Details on Person PHGDH tetramer dehydrogenates 3PG

Class:Id	Reaction:977348
_displayName	PHGDH tetramer dehydrogenates 3PG
_doRelease	TRUE
_timestamp	2024-11-26 00:03:34
authored	[InstanceEdit:977335] Stephan, R, 2010-10-16
catalystActivity	[CatalystActivity:977334] phosphoglycerate dehydrogenase activity of PHGDH tetramer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:977325] Jassal, B, 2010-10-18
crossReference	[DatabaseIdentifier:9929446] RHEA:12642
edited	[InstanceEdit:977325] Jassal, B, 2010-10-18
input	[SimpleEntity:29728] 3PG [cytosol] [SimpleEntity:29360] NAD+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:977338] Novel mutations in 3-phosphoglycerate dehydrogenase (PHGDH) are distributed throughout the protein and result in altered enzyme kinetics
modified	[InstanceEdit:977351] Jassal, B, 2010-10-18 [InstanceEdit:977406] Jassal, B, 2010-10-19 [InstanceEdit:1801596] Jassal, B, 2011-10-24 [InstanceEdit:1801597] Jassal, B, 2011-10-24 [InstanceEdit:1828026] Jassal, B, 2011-10-26 [InstanceEdit:9644778] Jassal, Bijay, 2019-04-23 [InstanceEdit:9751194] Jassal, Bijay, 2021-08-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929424] D'Eustachio, Peter, 2024-11-26
name	PHGDH tetramer dehydrogenates 3PG (2R)-3-phosphoglycerate + NAD(+) => 3-phosphooxypyruvate + H(+) + NADH 3-phosphoglycerate is dehydrogenated
output	[SimpleEntity:977329] 3POPA [cytosol] [SimpleEntity:73473] NADH [cytosol] [SimpleEntity:70106] H+ [cytosol]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1828027] D'Eustachio, P, 2011-10-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016643] R-HSA-977348.5
summation	[Summation:977405] Serine biosynthesis starts from 3-phosphoglycerate (3PG), a ...
(hasEvent)	[Pathway:977347] Serine metabolism [Homo sapiens]
(precedingEvent)	[Reaction:977333] PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA [Homo sapiens] [Reaction:9856871] MDH1 reduces OA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775437] Update Tracker - [Reaction:977348] PHGDH tetramer dehydrogenates 3PG - v79:[modifyText] [_UpdateTracker:9777668] Update Tracker - [Reaction:977348] PHGDH tetramer dehydrogenates 3PG - v69:[modifyText]
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No pathways have been reviewed or authored by PHGDH tetramer dehydrogenates 3PG (977348)