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Details on Person UniProt:B5TVM2-7 Ildr2
| Class:Id | ReferenceIsoform:9773305 |
|---|---|
| _chainChangeLog | signal peptide:1-35 for 9773305 added on Wed May 4 2022;chain:36-661 for 9773305 added on Wed May 4 2022 |
| _displayName | UniProt:B5TVM2-7 Ildr2 |
| _timestamp | 2024-08-09 19:31:18 |
| chain | signal peptide:1-35 chain:36-661 |
| checksum | E80BEDD0D21D5DA2 |
| comment | FUNCTION May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion (PubMed:23826244, PubMed:33863978). With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (PubMed:23239027). Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694). In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (PubMed:28785060).SUBUNIT Interacts with MARVELD2 and OCLN (PubMed:23239027). Interacts with P4HB and HSPA5; the interaction with HSPA5 stabilizes ILDR2 expression (PubMed:33863978). Interacts (via C-terminus) with TRA2A, TRA2B and SRSF1 (PubMed:28785060).SUBCELLULAR LOCATION Expressed in epithelial tissues, mainly in liver, kidney and colon.DISRUPTION PHENOTYPE Steatotic liver with increased hepatic and circulating triglycerides and total cholesterol. Shows reduced expression of genes mediating synthesis and oxidation of hepatic lipids.SIMILARITY Belongs to the immunoglobulin superfamily. LISCH7 family.CAUTION It is uncertain whether Met-1 or Met-16 is the initiator. |
| created | [InstanceEdit:9773244] Weiser, Joel |
| description | recommendedName: fullName evidence="12"Immunoglobulin-like domain-containing receptor 2 alternativeName: fullName evidence="10 11"Angulin-3 alternativeName: fullName evidence="9"Lisch-like protein |
| geneName | Ildr2 D1Ertd471e Ll |
| identifier | B5TVM2 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell junction Disulfide bond Endoplasmic reticulum Immunoglobulin domain Membrane Methylation Nucleus Phosphoprotein Reference proteome Signal Tight junction Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | Ildr2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ILDR2_MOUSE B5TVM3 B5TVM4 B5TVM5 B5TVM6 B5TVM7 B5TVM8 B5TVM9 E9Q9U5 |
| sequenceLength | 661 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | B5TVM2-7 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:B5TVM2-7 Ildr2 (9773305)
