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Details on Person Based on studies in mouse, the transcription factor SOX10, e...

Class:IdSummation:9773207
_displayNameBased on studies in mouse, the transcription factor SOX10, e...
_timestamp2022-05-25 14:40:27
created[InstanceEdit:9773209] Orlic-Milacic, Marija, 2022-05-02
literatureReference[LiteratureReference:9773180] Direct Interaction of Sox10 With Cadherin-19 Mediates Early Sacral Neural Crest Cell Migration: Implications for Enteric Nervous System Development Defects
[LiteratureReference:9773196] Genomic analysis reveals distinct mechanisms and functional classes of SOX10-regulated genes in melanocytes
modified[InstanceEdit:9774540] Orlic-Milacic, Marija, 2022-05-25
textBased on studies in mouse, the transcription factor SOX10, essential for migration of neural crest cells during formation of the enteric nervous system, binds CDH19 gene promoter and stimulates CDH19 transcription. Cdh19 knockdown results in retarded sacral migration of neural crest cells, while re-expression of Cdh19 partially rescues retarded migration of Sox10-null neural crest cells (Huang et al. 2022). Binding of SOX10 to the CDH19 gene promoter was also demonstrated in mouse melanocytes, but Cdh19 was not found to be differentially expressed in melanocytes upon Sox10 gene knockout (Fufa et al. 2015).
(summation)[Reaction:9773192] SOX10 binds CDH19 gene promoter [Homo sapiens]
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