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Details on Person Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2

Class:Id	Reaction:977239
_displayName	Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2
_doRelease	TRUE
_timestamp	2017-09-25 21:18:29
authored	[InstanceEdit:1094913] Shamovsky, V, 2010-11-30
catalystActivity	[CatalystActivity:977242] protein serine/threonine kinase activity of IRAK2 : p-IRAK4 :MyD88 : activated TLR [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:977249] Shamovsky, V, 2010-10-15
edited	[InstanceEdit:1221606] Shamovsky, V, 2011-02-24
inferredFrom	[Reaction:975861] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex [Homo sapiens]
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:977244] IRAK2 : p-IRAK4 :MyD88 : activated TLR [plasma membrane] [Gallus gallus]
literatureReference	[LiteratureReference:446698] Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2
modified	[InstanceEdit:1063706] Shamovsky, V, 2010-11-25 [InstanceEdit:1216499] Shamovsky, V, 2011-02-14 [InstanceEdit:1220566] Shamovsky, V, 2011-02-21 [InstanceEdit:1221611] Shamovsky, V, 2011-02-24 [InstanceEdit:5621492] Shamovsky, V, 2014-08-29 [InstanceEdit:9022891] Shamovsky, Veronica, 2017-09-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2
output	[Complex:977233] p-IRAK2 : p-IRAK4 : activated TLR : MyD88 [plasma membrane] [Gallus gallus] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:977237] IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex [Gallus gallus] [Reaction:977250] Autophosphorylation of IRAK4 bound to activated TLR5 or 15 [Gallus gallus]
relatedSpecies	[Species:451465] Salmonella typhimurium
releaseDate	2011-03-15
reviewed	[InstanceEdit:1112618] D'Eustachio, P, 2010-12-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1225061] R-GGA-977239.3
summation	[Summation:570878] In mammals activated IRAK4 phosphorylates both IRAK1 and IRA...
(hasEvent)	[Pathway:977240] MyD88 cascade initiated on plasma membrane [Gallus gallus]
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No pathways have been reviewed or authored by Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2 (977239)