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Details on Person IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex

Class:Id	Reaction:977237
_displayName	IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex
_doRelease	TRUE
_timestamp	2017-09-25 21:22:26
authored	[InstanceEdit:1094913] Shamovsky, V, 2010-11-30
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:977249] Shamovsky, V, 2010-10-15
edited	[InstanceEdit:1221606] Shamovsky, V, 2011-02-24
inferredFrom	[Reaction:975852] IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex [Homo sapiens]
input	[EntityWithAccessionedSequence:434068] IRAK2 [cytosol] [Gallus gallus] [EntityWithAccessionedSequence:434068] IRAK2 [cytosol] [Gallus gallus] [Complex:977234] activated TLR : MyD88 : p-IRAK4 [plasma membrane] [Gallus gallus]
literatureReference	[LiteratureReference:434579] The avian Toll-Like receptor pathway--subtle differences amidst general conformity [LiteratureReference:446698] Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2
modified	[InstanceEdit:1063706] Shamovsky, V, 2010-11-25 [InstanceEdit:1216499] Shamovsky, V, 2011-02-14 [InstanceEdit:1220566] Shamovsky, V, 2011-02-21 [InstanceEdit:1221615] Shamovsky, V, 2011-02-24 [InstanceEdit:5621492] Shamovsky, V, 2014-08-29 [InstanceEdit:9022896] Shamovsky, Veronica, 2017-09-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex
output	[Complex:977244] IRAK2 : p-IRAK4 :MyD88 : activated TLR [plasma membrane] [Gallus gallus]
precedingEvent	[Reaction:977250] Autophosphorylation of IRAK4 bound to activated TLR5 or 15 [Gallus gallus] [Reaction:434130] IRAK4 binds to activated TLR5 or 15 [Gallus gallus]
relatedSpecies	[Species:451465] Salmonella typhimurium
releaseDate	2011-03-15
reviewed	[InstanceEdit:1112618] D'Eustachio, P, 2010-12-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1225032] R-GGA-977237.3
summation	[Summation:570878] In mammals activated IRAK4 phosphorylates both IRAK1 and IRA...
(hasEvent)	[Pathway:977240] MyD88 cascade initiated on plasma membrane [Gallus gallus]
(precedingEvent)	[Reaction:977239] Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2 [Gallus gallus]
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No pathways have been reviewed or authored by IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex (977237)