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Details on Person NLRP3 activation by mtDNA

Class:Id	BlackBoxEvent:9771253
_displayName	NLRP3 activation by mtDNA
_timestamp	2022-04-22 00:25:20
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9771258] Shamovsky, Veronica, 2022-04-18
input	[Complex:874086] NLRP3:SUGT1:HSP90 [cytosol] [Homo sapiens] [Complex:9771259] 8-OHdG-mtDNA [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9772370] New mitochondrial DNA synthesis enables NLRP3 inflammasome activation [LiteratureReference:9772368] Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
modified	[InstanceEdit:9772362] Shamovsky, Veronica, 2022-04-22
name	NLRP3 activation by mtDNA
output	[Complex:874112] SUGT1:HSP90 [cytosol] [Homo sapiens] [Complex:9771252] NLRP3:oxidized mtDNA [Homo sapiens]
precedingEvent	[Reaction:873951] SGT1:HSP90 binds inactive NLRP3 [Homo sapiens] [Reaction:874087] SGT1 binds HSP90 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9771265] R-HSA-9771253.1
summation	[Summation:9771254] The NLRP3 inflammasome is activated by a range of stimuli of...
(hasEvent)	[Pathway:844456] The NLRP3 inflammasome [Homo sapiens]
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No pathways have been reviewed or authored by NLRP3 activation by mtDNA (9771253)