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Details on Person "MYC binds directly to WDR5 via an invariant sequence motif ...

Class:IdSummation:9770995
_displayName"MYC binds directly to WDR5 via an invariant sequence motif ...
_timestamp2022-04-18 13:22:57
created[InstanceEdit:9770994] Orlic-Milacic, Marija, 2022-04-18
literatureReference[LiteratureReference:9770998] Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC
modified[InstanceEdit:9771032] Orlic-Milacic, Marija, 2022-04-18
text"MYC binds directly to WDR5 via an invariant sequence motif present in all extant MYC proteins. This motif is almost identical to the WBM of RBBP5 and KANSL2, and structural analyses showed that MYC interacts with WDR5 via the WBM site. WDR5 and MYC co-localize on chromatin, and mutations in MYC that disrupt the interaction do not impact the binding of WDR5 to chromatin, but they do prevent MYC from stably associating with its target genes and from driving tumorigenesis in mice (Thomas et al. 2015). Thus, the MYC–WDR5 interaction facilitates the recruitment of MYC to target gene chromatin, which is a function that does not depend on enzymatic activity. Additionally, MYC’s requirement for direct contact with the WBM of WDR5 to bind a multitude of sites across the genome reveals that, at any moment in time, a significant fraction of chromatin-bound WDR5 is not in its SET1/MLL- or NSL-complexed states.
(summation)[Reaction:9674855] MYC binds WDR5 at target gene promoters [Homo sapiens]
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