Query author contributions in Reactome
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Details on Person Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) tra...
| Class:Id | Summation:977074 |
|---|---|
| _displayName | Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) tra... |
| _timestamp | 2021-10-12 13:49:08 |
| created | [InstanceEdit:977066] Jassal, B, 2010-10-15 |
| literatureReference | [LiteratureReference:9756080] ST6GalNAc-I promotes lung cancer metastasis by altering MUC5AC sialylation |
| modified | [InstanceEdit:981810] Jassal, B, 2010-10-27 [InstanceEdit:4088185] Jassal, Bijay, 2013-08-12 [InstanceEdit:9756078] Jassal, Bijay, 2021-10-12 [InstanceEdit:9756127] Jassal, Bijay, 2021-10-12 |
| text | Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) transfers sialic acid (Neu5Ac) from the donor CMP-Neu5Ac to galactose-containing acceptor substrates such as Tn antigens (Stamenkovic et al. 1990, Marcos et al. 2004). The resultant sialyl Tn antigens are highly expressed in several human carcinomas and are associated with carcinoma aggressiveness and poor prognosis (Sewell et al. 2006, Lakshmanan et al. 2021). |
| (summation) | [Reaction:977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens [Homo sapiens] |
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No pathways have been reviewed or authored by Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) tra... (977074)
