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Details on Person Formation of the Spliceosomal P complex and exon ligation
Class:Id BlackBoxEvent:9770236 _displayName Formation of the Spliceosomal P complex and exon ligation _doRelease TRUE _timestamp 2023-03-06 17:26:04 authored [InstanceEdit:9770244] May, Bruce, 2022-03-30 catalystActivity [CatalystActivity:9794538] second spliceosomal transesterification activity of Spliceosomal C* complex [nucleoplasm] compartment [Compartment:7660] nucleoplasm created [InstanceEdit:9770237] May, Bruce, 2022-03-30 edited [InstanceEdit:9770244] May, Bruce, 2022-03-30 input [Complex:9770118] Spliceosomal C* complex [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9769588] C9orf78 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9769590] LENG1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9769602] NKAP [nucleoplasm] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:8984694] The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans [LiteratureReference:8850665] Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA [LiteratureReference:6806800] Rearrangements within human spliceosomes captured after exon ligation [LiteratureReference:9769585] A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation [LiteratureReference:927736] A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex [LiteratureReference:9770778] Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core [LiteratureReference:9769600] Structures of the human spliceosomes before and after release of the ligated exon [LiteratureReference:9770783] An Atomic Structure of the Human Spliceosome [LiteratureReference:9770792] Cryo-EM structure of a human spliceosome activated for step 2 of splicing [LiteratureReference:9772727] Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex components modified [InstanceEdit:9770447] May, Bruce, 2022-04-04 [InstanceEdit:9770577] May, Bruce, 2022-04-07 [InstanceEdit:9770595] May, Bruce, 2022-04-07 [InstanceEdit:9770649] May, Bruce, 2022-04-10 [InstanceEdit:9770798] May, Bruce, 2022-04-14 [InstanceEdit:9770930] May, Bruce, 2022-04-15 [InstanceEdit:9772096] May, Bruce, 2022-04-20 [InstanceEdit:9772750] May, Bruce, 2022-04-23 [InstanceEdit:9794546] May, Bruce, 2022-07-13 [InstanceEdit:9818132] May, Bruce, 2022-10-12 [InstanceEdit:9818819] May, Bruce, 2022-10-22 [InstanceEdit:9830333] May, Bruce, 2023-03-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Formation of the Spliceosomal P complex and exon ligation output [Complex:9769587] Spliceosomal P complex [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9769562] PPIL2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8952113] PPIL4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5688093] PRPF18 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8849139] DDX39B [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6791189] SKIV2L2 [nucleoplasm] [Homo sapiens] precedingEvent
releaseDate 2022-12-07 reviewed [InstanceEdit:9818818] Charenton, Clément, 2022-10-20 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9770264] R-HSA-9770236.3 summation [Summation:9772092] Two magnesium ions coordinated by 4 phosphate groups of the ... (hasEvent) [Pathway:72163] mRNA Splicing - Major Pathway [Homo sapiens] [Pathway:9770130] mRNA Splicing - Major Pathway (update) [Homo sapiens] (precedingEvent) [BlackBoxEvent:9770847] Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) [Homo sapiens] (replacementInstances) [_Deleted:9830329] Deletion of instance: 72160
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