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Details on Person Formation of the Spliceosomal B complex

Class:IdBlackBoxEvent:9770142
_displayNameFormation of the Spliceosomal B complex
_doReleaseTRUE
_timestamp2023-03-06 17:25:31
authored[InstanceEdit:9769907] May, Bruce, 2022-03-22
catalystActivity[CatalystActivity:9770929] RNA helicase activity of Spliceosomal Pre-B complex [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9770146] May, Bruce, 2022-03-24
edited[InstanceEdit:9769907] May, Bruce, 2022-03-22
input[Complex:9769528] Spliceosomal Pre-B complex [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:8867887] WBP11 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:8867889] PQBP1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9770255] UBL5 [nucleoplasm] [Homo sapiens]
[DefinedSet:9770781] ASAP complex, PSAP complex [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
[EntityWithAccessionedSequence:8867895] WBP4 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:2396419] MFAP1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:8867897] PRPF38A [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9770248] ZMAT2 [nucleoplasm] [Homo sapiens]
[Complex:9769523] RES complex [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:72117] Large-scale proteomic analysis of the human spliceosome.
[LiteratureReference:5566502] Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions
[LiteratureReference:9769583] Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes
[LiteratureReference:9769580] Structure of the human activated spliceosome in three conformational states
[LiteratureReference:6806809] Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis
[LiteratureReference:9770574] Mass spectrometry-based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count
[LiteratureReference:8865916] Isolation of an active step I spliceosome and composition of its RNP core
[LiteratureReference:9772624] Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation
[LiteratureReference:9770241] A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity
[LiteratureReference:9772622] Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28
[LiteratureReference:9772614] The 100-kda U5 snRNP protein (hPrp28p) contacts the 5' splice site through its ATPase site
[LiteratureReference:9772724] Exon, intron and splice site locations in the spliceosomal B complex
[LiteratureReference:9818098] Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5' splice site
[LiteratureReference:9769531] Mechanism of 5' splice site transfer for human spliceosome activation
modified[InstanceEdit:9770221] May, Bruce, 2022-03-26
[InstanceEdit:9770277] May, Bruce, 2022-03-30
[InstanceEdit:9770447] May, Bruce, 2022-04-04
[InstanceEdit:9770577] May, Bruce, 2022-04-07
[InstanceEdit:9770579] May, Bruce, 2022-04-07
[InstanceEdit:9770595] May, Bruce, 2022-04-07
[InstanceEdit:9770649] May, Bruce, 2022-04-10
[InstanceEdit:9770798] May, Bruce, 2022-04-14
[InstanceEdit:9770930] May, Bruce, 2022-04-15
[InstanceEdit:9771088] May, Bruce, 2022-04-18
[InstanceEdit:9771910] May, Bruce, 2022-04-20
[InstanceEdit:9772626] May, Bruce, 2022-04-22
[InstanceEdit:9772726] May, Bruce, 2022-04-23
[InstanceEdit:9773235] May, Bruce, 2022-05-03
[InstanceEdit:9773577] May, Bruce, 2022-05-06
[InstanceEdit:9794540] May, Bruce, 2022-07-13
[InstanceEdit:9794546] May, Bruce, 2022-07-13
[InstanceEdit:9818132] May, Bruce, 2022-10-12
[InstanceEdit:9818819] May, Bruce, 2022-10-22
[InstanceEdit:9830333] May, Bruce, 2023-03-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameFormation of the Spliceosomal B complex
output[EntityWithAccessionedSequence:8867890] PRPF40A [nucleoplasm] [Homo sapiens]
[Complex:9770126] Spliceosomal B complex [nucleoplasm] [Homo sapiens]
[Complex:71917] U1 snRNP [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9770250] RBM25 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9770254] RBM39 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:72049] RBM5 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9769525] PRPF4B [nucleoplasm] [Homo sapiens]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113550] Pi [nucleoplasm]
[EntityWithAccessionedSequence:9769526] RBM42 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:6806778] SNRNP27 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:6806793] USP39 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:4615999] SART1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:71879] DDX23 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2022-12-07
reviewed[InstanceEdit:9818818] Charenton, Clément, 2022-10-20
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9770147] R-HSA-9770142.3
summation[Summation:9771074] The DDX23 RNA helicase (homolog of yeast Prp28) binds ATP to...
(hasEvent)[Pathway:72163] mRNA Splicing - Major Pathway [Homo sapiens]
[Pathway:9770130] mRNA Splicing - Major Pathway (update) [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9770145] Formation of the Spliceosomal Bact complex [Homo sapiens]
(replacementInstances)[_Deleted:9830324] Deletion of instance: 72127
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