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Details on Person Formation of the Spliceosomal C* complex
Class:Id BlackBoxEvent:9770141 _displayName Formation of the Spliceosomal C* complex _doRelease TRUE _timestamp 2023-03-06 17:25:54 authored [InstanceEdit:9769907] May, Bruce, 2022-03-22 catalystActivity [CatalystActivity:9770421] RNA helicase activity of Spliceosomal C complex [nucleoplasm] catalystActivityReference [CatalystActivityReference:9643243] ATPase activity of Spliceosomal Intermediate C (Bact) Complex [nucleoplasm] Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing compartment [Compartment:7660] nucleoplasm created [InstanceEdit:9770146] May, Bruce, 2022-03-24 edited [InstanceEdit:9769907] May, Bruce, 2022-03-22 input [Complex:9770138] Spliceosomal C complex [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5688092] DHX8 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:72073] hSLU7 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5688093] PRPF18 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9769591] CACTIN [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9769601] DDX41 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9769596] STEEP1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9769593] SDE2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9769599] FAM50A [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9769594] PRKRIP1 [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:9769598] FAM32A [nucleoplasm] [Homo sapiens] literatureReference [LiteratureReference:72132] Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. [LiteratureReference:72117] Large-scale proteomic analysis of the human spliceosome. [LiteratureReference:6806800] Rearrangements within human spliceosomes captured after exon ligation [LiteratureReference:9769583] Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes [LiteratureReference:5566504] Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome [LiteratureReference:9770783] An Atomic Structure of the Human Spliceosome [LiteratureReference:9770792] Cryo-EM structure of a human spliceosome activated for step 2 of splicing [LiteratureReference:9772739] Retinitis pigmentosa-linked mutation in DHX38 modulates its splicing activity [LiteratureReference:9772746] Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing [LiteratureReference:9772742] The mammalian homologue of Prp16p is overexpressed in a cell line tolerant to Leflunomide, a new immunoregulatory drug effective against rheumatoid arthritis [LiteratureReference:9772729] A missense mutation in the splicing factor gene DHX38 is associated with early-onset retinitis pigmentosa with macular coloboma modified [InstanceEdit:9770221] May, Bruce, 2022-03-26 [InstanceEdit:9770447] May, Bruce, 2022-04-04 [InstanceEdit:9770649] May, Bruce, 2022-04-10 [InstanceEdit:9770798] May, Bruce, 2022-04-14 [InstanceEdit:9770930] May, Bruce, 2022-04-15 [InstanceEdit:9771910] May, Bruce, 2022-04-20 [InstanceEdit:9772726] May, Bruce, 2022-04-23 [InstanceEdit:9772750] May, Bruce, 2022-04-23 [InstanceEdit:9794546] May, Bruce, 2022-07-13 [InstanceEdit:9818132] May, Bruce, 2022-10-12 [InstanceEdit:9818819] May, Bruce, 2022-10-22 [InstanceEdit:9830333] May, Bruce, 2023-03-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Formation of the Spliceosomal C* complex output [Complex:9770118] Spliceosomal C* complex [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8867898] CWC25 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9770430] YJU2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9770425] WDR70 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:72060] DHX38 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9770419] GPATCH1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9770427] DHX35 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9770428] NSRP1 [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113550] Pi [nucleoplasm] precedingEvent
releaseDate 2022-12-07 reviewed [InstanceEdit:9818818] Charenton, Clément, 2022-10-20 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9770149] R-HSA-9770141.3 summation [Summation:9771901] DHX38 (homolog of yeast Prp16) hydrolyzes ATP to remodel the... (hasEvent) [Pathway:72163] mRNA Splicing - Major Pathway [Homo sapiens] [Pathway:9770130] mRNA Splicing - Major Pathway (update) [Homo sapiens] (precedingEvent) [BlackBoxEvent:9770236] Formation of the Spliceosomal P complex and exon ligation [Homo sapiens] (replacementInstances) [_Deleted:9830332] Deletion of instance: 72139
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