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Details on Person Formation of the Spliceosomal Pre-B complex

Class:Id	BlackBoxEvent:9770132
_displayName	Formation of the Spliceosomal Pre-B complex
_doRelease	TRUE
_timestamp	2025-11-04 07:15:45
authored	[InstanceEdit:9769907] May, Bruce, 2022-03-22
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9770146] May, Bruce, 2022-03-24
edited	[InstanceEdit:9769907] May, Bruce, 2022-03-22
input	[Complex:77506] U4:U5:U6 tri-snRNP complex [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9769525] PRPF4B [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9770239] IK [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6791189] SKIV2L2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8849139] DDX39B [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9770259] SMU1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:156649] ALYREF [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:156781] SRRM1 [nucleoplasm] [Homo sapiens] [Complex:9970412] Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9971060] Matthews, Lisa, 2025-10-30
isChimeric	FALSE
literatureReference	[LiteratureReference:9770241] A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity [LiteratureReference:9769531] Mechanism of 5' splice site transfer for human spliceosome activation [LiteratureReference:9769529] Structures of the human pre-catalytic spliceosome and its precursor spliceosome [LiteratureReference:9769520] Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation [LiteratureReference:9769583] Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes [LiteratureReference:8850665] Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA [LiteratureReference:927736] A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex [LiteratureReference:9771906] Evidence for base-pairing between mammalian U2 and U6 small nuclear ribonucleoprotein particles [LiteratureReference:9818098] Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5' splice site
modified	[InstanceEdit:9770221] May, Bruce, 2022-03-26 [InstanceEdit:9770277] May, Bruce, 2022-03-30 [InstanceEdit:9770447] May, Bruce, 2022-04-04 [InstanceEdit:9770577] May, Bruce, 2022-04-07 [InstanceEdit:9770595] May, Bruce, 2022-04-07 [InstanceEdit:9770798] May, Bruce, 2022-04-14 [InstanceEdit:9771088] May, Bruce, 2022-04-18 [InstanceEdit:9771910] May, Bruce, 2022-04-20 [InstanceEdit:9794540] May, Bruce, 2022-07-13 [InstanceEdit:9818132] May, Bruce, 2022-10-12 [InstanceEdit:9818819] May, Bruce, 2022-10-22 [InstanceEdit:9830333] May, Bruce, 2023-03-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9971062] Orlic-Milacic, Marija, 2025-11-04
name	Formation of the Spliceosomal Pre-B complex
output	[Complex:9769528] Spliceosomal Pre-B complex [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:72048] CCAR1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:53703] DNAJC8 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9770246] HTATSF1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9770253] PPP1R8 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:72043] SUGP1 [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9770129] Formation of the Spliceosomal A complex [Homo sapiens] [BlackBoxEvent:9770119] Formation of the Spliceosomal E complex [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2022-12-07
reviewed	[InstanceEdit:9818818] Charenton, Cl�ment, 2022-10-20
reviewStatus	[ReviewStatus:9821385] four stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9770163] R-HSA-9770132.4
structureModified	[InstanceEdit:9971062] Orlic-Milacic, Marija, 2025-11-04
summation	[Summation:9770263] The U4/U6.U5 tri-snRNP complex loosely binds the Spliceosoma...
(hasEvent)	[Pathway:72163] mRNA Splicing - Major Pathway [Homo sapiens] [Pathway:9770130] mRNA Splicing - Major Pathway (update) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9770142] Formation of the Spliceosomal B complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9971887] Update Tracker - [BlackBoxEvent:9770132] Formation of the Spliceosomal Pre-B complex - v95:[add_removeInput]
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No pathways have been reviewed or authored by Formation of the Spliceosomal Pre-B complex (9770132)