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Details on Person Formation of the Spliceosomal E complex
Class:Id BlackBoxEvent:9770119
_displayName Formation of the Spliceosomal E complex
_doRelease TRUE
_timestamp 2023-03-06 17:25:59
authored [InstanceEdit:9769907] May, Bruce, 2022-03-22
compartment [Compartment:7660] nucleoplasm
created [InstanceEdit:9770146] May, Bruce, 2022-03-24
edited [InstanceEdit:9769907] May, Bruce, 2022-03-22
input [Complex:71917] U1 snRNP [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:53517] DHX9 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:72043] SUGP1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3900136] DDX5 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6814858] SRRT [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8865928] SF1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8867890] PRPF40A [nucleoplasm] [Homo sapiens] [Complex:9770256] U2AF [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9770250] RBM25 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9770254] RBM39 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8985564] RBM7 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9770258] LUC7L3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9770246] HTATSF1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8865888] SRRM2 [nucleoplasm] [Homo sapiens] [Complex:71955] capped, methylated pre-mRNP:CBC complex [nucleoplasm] [Homo sapiens]
literatureReference [LiteratureReference:72109] Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method. [LiteratureReference:72117] Large-scale proteomic analysis of the human spliceosome. [LiteratureReference:8850757] Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs [LiteratureReference:8865895] Dynamic protein-protein interaction wiring of the human spliceosome [LiteratureReference:8865896] Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins [LiteratureReference:9770231] Association of U2 snRNP with the spliceosomal complex E [LiteratureReference:9770219] Functional association of U2 snRNP with the ATP-independent spliceosomal complex E [LiteratureReference:9771902] A compensatory base change in U1 snRNA suppresses a 5' splice site mutation [LiteratureReference:9771897] Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition [LiteratureReference:9771907] Noncanonical registers and base pairs in human 5' splice-site selection [LiteratureReference:9773571] A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition [LiteratureReference:9818109] Structure of a transcribing RNA polymerase II-U1 snRNP complex
modified [InstanceEdit:9770221] May, Bruce, 2022-03-26 [InstanceEdit:9770277] May, Bruce, 2022-03-30 [InstanceEdit:9770447] May, Bruce, 2022-04-04 [InstanceEdit:9770577] May, Bruce, 2022-04-07 [InstanceEdit:9771910] May, Bruce, 2022-04-20 [InstanceEdit:9773158] May, Bruce, 2022-04-30 [InstanceEdit:9773578] May, Bruce, 2022-05-06 [InstanceEdit:9794540] May, Bruce, 2022-07-13 [InstanceEdit:9818132] May, Bruce, 2022-10-12 [InstanceEdit:9818819] May, Bruce, 2022-10-22 [InstanceEdit:9830333] May, Bruce, 2023-03-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name Formation of the Spliceosomal E complex
output [Complex:9770121] Spliceosomal E complex [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate 2022-12-07
reviewed [InstanceEdit:9818818] Charenton, Clément, 2022-10-20
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:9770165] R-HSA-9770119.3
summation [Summation:9770226] Splicing of pre-mRNAs occurs co-transcriptionally in mammals...
(hasEvent) [Pathway:72163] mRNA Splicing - Major Pathway [Homo sapiens] [Pathway:9770130] mRNA Splicing - Major Pathway (update) [Homo sapiens]
(precedingEvent) [BlackBoxEvent:9770129] Formation of the Spliceosomal A complex [Homo sapiens]
(replacementInstances) [_Deleted:9830325] Deletion of instance: 72107
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