Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Formation of the Spliceosomal E complex

Class:IdBlackBoxEvent:9770119
_displayNameFormation of the Spliceosomal E complex
_doReleaseTRUE
_timestamp2023-03-06 17:25:59
authored[InstanceEdit:9769907] May, Bruce, 2022-03-22
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9770146] May, Bruce, 2022-03-24
edited[InstanceEdit:9769907] May, Bruce, 2022-03-22
input[Complex:71917] U1 snRNP [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:53517] DHX9 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:72043] SUGP1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:3900136] DDX5 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:6814858] SRRT [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:8865928] SF1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:8867890] PRPF40A [nucleoplasm] [Homo sapiens]
[Complex:9770256] U2AF [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9770250] RBM25 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9770254] RBM39 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:8985564] RBM7 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9770258] LUC7L3 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9770246] HTATSF1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:8865888] SRRM2 [nucleoplasm] [Homo sapiens]
[Complex:71955] capped, methylated pre-mRNP:CBC complex [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:72109] Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method.
[LiteratureReference:72117] Large-scale proteomic analysis of the human spliceosome.
[LiteratureReference:8850757] Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs
[LiteratureReference:8865895] Dynamic protein-protein interaction wiring of the human spliceosome
[LiteratureReference:8865896] Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins
[LiteratureReference:9770231] Association of U2 snRNP with the spliceosomal complex E
[LiteratureReference:9770219] Functional association of U2 snRNP with the ATP-independent spliceosomal complex E
[LiteratureReference:9771902] A compensatory base change in U1 snRNA suppresses a 5' splice site mutation
[LiteratureReference:9771897] Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition
[LiteratureReference:9771907] Noncanonical registers and base pairs in human 5' splice-site selection
[LiteratureReference:9773571] A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition
[LiteratureReference:9818109] Structure of a transcribing RNA polymerase II-U1 snRNP complex
modified[InstanceEdit:9770221] May, Bruce, 2022-03-26
[InstanceEdit:9770277] May, Bruce, 2022-03-30
[InstanceEdit:9770447] May, Bruce, 2022-04-04
[InstanceEdit:9770577] May, Bruce, 2022-04-07
[InstanceEdit:9771910] May, Bruce, 2022-04-20
[InstanceEdit:9773158] May, Bruce, 2022-04-30
[InstanceEdit:9773578] May, Bruce, 2022-05-06
[InstanceEdit:9794540] May, Bruce, 2022-07-13
[InstanceEdit:9818132] May, Bruce, 2022-10-12
[InstanceEdit:9818819] May, Bruce, 2022-10-22
[InstanceEdit:9830333] May, Bruce, 2023-03-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameFormation of the Spliceosomal E complex
output[Complex:9770121] Spliceosomal E complex [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2022-12-07
reviewed[InstanceEdit:9818818] Charenton, Clément, 2022-10-20
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9770165] R-HSA-9770119.3
summation[Summation:9770226] Splicing of pre-mRNAs occurs co-transcriptionally in mammals...
(hasEvent)[Pathway:72163] mRNA Splicing - Major Pathway [Homo sapiens]
[Pathway:9770130] mRNA Splicing - Major Pathway (update) [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9770129] Formation of the Spliceosomal A complex [Homo sapiens]
(replacementInstances)[_Deleted:9830325] Deletion of instance: 72107
[Change default viewing format]
No pathways have been reviewed or authored by Formation of the Spliceosomal E complex (9770119)