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Details on Person In rat primary neurons, Npas4 directly activates Syt10 gene ...
| Class:Id | Summation:9770070 |
|---|---|
| _displayName | In rat primary neurons, Npas4 directly activates Syt10 gene ... |
| _timestamp | 2024-11-04 18:00:31 |
| created | [InstanceEdit:9770076] Orlic-Milacic, Marija, 2022-03-24 |
| literatureReference | [LiteratureReference:9769283] Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration |
| modified | [InstanceEdit:9927067] Orlic-Milacic, Marija, 2024-11-04 |
| text | In rat primary neurons, Npas4 directly activates Syt10 gene transcription (Woitecki et al. 2016). The Syt10 gene encodes Synaptotagmin-10, a Ca2+ sensor required for Ca2+-dependent exocytosis of secretory vesicles in neurons. Syt10 was identified as one of the core activity-regulated inhibitors of death (AID) genes, that exhibit neuroprotective effect by preventing excitotoxicity-induced neuronal cell death (Woitecki et al. 2016). |
| (summation) | [BlackBoxEvent:9770074] Npas4 stimulates Syt10 gene expression [Rattus norvegicus] |
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No pathways have been reviewed or authored by In rat primary neurons, Npas4 directly activates Syt10 gene ... (9770070)
