Query author contributions in Reactome Reactome depends on collaboration between our curation team and outside experts to
assemble and peer-review its pathway modules. The integration of ORCID within Reactome
enables us to meet a key challenge with authoring, curating and reviewing biological
information by incentivizing and crediting the external experts that contribute their
expertise and time to the Reactome curation process. More information is available at
ORCID and Reactome .
If you have an ORCID ID that is not listed on this page, please
forward this information to us and we will update your Reactome pathway records.
Details on Person FURIN Mediated SARS-CoV-2 Spike Protein Cleavage
Class:Id Reaction:9769949 _displayName FURIN Mediated SARS-CoV-2 Spike Protein Cleavage _doRelease TRUE _timestamp 2022-08-18 10:00:42 authored [InstanceEdit:9769947] Stephan, Ralf, 2022-03-23 catalystActivity [CatalystActivity:2159870] serine-type endopeptidase activity of FURIN [plasma membrane] compartment [Compartment:876] plasma membrane created [InstanceEdit:9769951] Stephan, Ralf, 2022-03-23 disease [Disease:9683912] COVID-19 edited [InstanceEdit:9796426] Stephan, Ralf, 2022-08-09 input [Complex:9770060] Spike trimer:ACE2 [plasma membrane] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:9699000] The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin [LiteratureReference:9765579] Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis [LiteratureReference:9765590] Furin cleavage of the SARS-CoV-2 spike is modulated by O -glycosylation [LiteratureReference:9698993] A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells [LiteratureReference:9767485] The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms [LiteratureReference:9733457] Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion [LiteratureReference:9770330] Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site [LiteratureReference:9770280] Proteolytic activation of SARS-CoV-2 spike protein [LiteratureReference:9770340] Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity modified [InstanceEdit:9770061] Stephan, Ralf, 2022-03-24 [InstanceEdit:9770215] Stephan, Ralf, 2022-03-26 [InstanceEdit:9770327] Stephan, Ralf, 2022-04-04 [InstanceEdit:9770339] Stephan, Ralf, 2022-04-04 [InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29 [InstanceEdit:9796131] Stephan, Ralf, 2022-08-05 [InstanceEdit:9815534] Stephan, Ralf, 2022-08-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name FURIN Mediated SARS-CoV-2 Spike Protein Cleavage output [Complex:9733494] S1 trimer:ACE2:S2 trimer [plasma membrane] [Homo sapiens] precedingEvent
regulatedBy [NegativeRegulation:9769499] Negative regulation by 'Spike:heparin [extracellular region]' regulationReference [RegulationReference:9769496] Negative regulation by 'Spike:heparin [extracellular region]' The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms relatedSpecies [Species:9681683] Severe acute respiratory syndrome coronavirus 2 releaseDate 2022-09-14 reviewed [InstanceEdit:9773891] Gillespie, Marc E, 2022-05-10 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9769953] R-HSA-9769949.2 summation [Summation:9770216] In a SARS-CoV-2 infection the cellular protease furin cleave... (hasEvent) [Pathway:9733458] Induction of Cell-Cell Fusion [Homo sapiens] (precedingEvent) [BlackBoxEvent:9770063] S1,S2 Dissociate from S1:ACE2:S2 [Homo sapiens]
[Change default viewing format]
List...
Protein identifiers
ChEBI identifiers
KEGG COMPOUND identifiers
No pathways have been reviewed or authored by FURIN Mediated SARS-CoV-2 Spike Protein Cleavage (9769949)
