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Details on Person Prolactin receptor ligands bind the prolactin receptor

Class:Id	Reaction:976991
_displayName	Prolactin receptor ligands bind the prolactin receptor
_doRelease	TRUE
_timestamp	2011-11-23 11:15:37
authored	[InstanceEdit:1363240] Jupe, S, 2011-06-13
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:976976] Jupe, S, 2010-10-14
edited	[InstanceEdit:1671724] Jupe, S, 2011-10-17
input	[DefinedSet:1172021] Prolactin receptor ligands [extracellular region] [Homo sapiens] [Complex:1364076] PRLR:JAK2 dimer [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1172026] Crystal structure and site 1 binding energetics of human placental lactogen
modified	[InstanceEdit:977422] Jupe, S, 2010-10-19 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1170541] Jupe, S, 2011-01-19 [InstanceEdit:1172024] Jupe, S, 2011-01-20 [InstanceEdit:1302681] Jupe, S, 2011-05-27 [InstanceEdit:1364048] Jupe, S, 2011-06-23 [InstanceEdit:1366608] Jupe, S, 2011-06-24 [InstanceEdit:1671654] Jupe, S, 2011-10-17 [InstanceEdit:1977932] Jupe, S, 2011-11-08 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Prolactin receptor ligands bind the prolactin receptor
output	[Complex:1671652] PRLR ligands:PRLR:JAK2 dimer [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1364044] PRLR:JAK2 dimerizes [Homo sapiens] [Reaction:1302698] PRLR associates with JAK2 [Homo sapiens]
regulatedBy	[NegativeRegulation:1370510] Negative regulation by 'PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane]'
releaseDate	2011-12-06
reviewed	[InstanceEdit:1977929] Goffin, V, 2011-11-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016626] R-HSA-976991.3
summation	[Summation:976966] Human PRLR binds at least 3 related peptide ligands namely p...
(hasEvent)	[Pathway:1170546] Prolactin receptor signaling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:1671687] PRLR activation [Homo sapiens]
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No pathways have been reviewed or authored by Prolactin receptor ligands bind the prolactin receptor (976991)