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Details on Person Spike Trimer Translocates to the Plasma Membrane

Class:Id	BlackBoxEvent:9769812
_displayName	Spike Trimer Translocates to the Plasma Membrane
_doRelease	TRUE
_timestamp	2022-08-18 10:01:18
authored	[InstanceEdit:9769814] Stephan, Ralf, 2022-03-22
compartment	[Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane [Compartment:876] plasma membrane
created	[InstanceEdit:9769813] Stephan, Ralf, 2022-03-22
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9796426] Stephan, Ralf, 2022-08-09
input	[Complex:9698334] fully glycosylated Spike trimer [endoplasmic reticulum-Golgi intermediate compartment membrane] [Severe acute respiratory syndrome coronavirus 2]
isChimeric	FALSE
literatureReference	[LiteratureReference:9733499] Syncytia formation by SARS-CoV-2-infected cells [LiteratureReference:9769807] Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation
modified	[InstanceEdit:9770179] Stephan, Ralf, 2022-03-25 [InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29 [InstanceEdit:9796131] Stephan, Ralf, 2022-08-05 [InstanceEdit:9815534] Stephan, Ralf, 2022-08-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Spike Trimer Translocates to the Plasma Membrane
output	[Complex:9733504] Spike trimer [plasma membrane] [Severe acute respiratory syndrome coronavirus 2]
precedingEvent	[BlackBoxEvent:9694780] Spike translocates to ERGIC [Homo sapiens] [Reaction:9694337] Trimmed spike protein binds to calnexin [Homo sapiens]
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-09-14
reviewed	[InstanceEdit:9773891] Gillespie, Marc E, 2022-05-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9769815] R-HSA-9769812.2
summation	[Summation:9769811] SARS-CoV-2 Spike protein (S) is present on the surface of in...
(hasEvent)	[Pathway:9733458] Induction of Cell-Cell Fusion [Homo sapiens]
(precedingEvent)	[Reaction:9733495] Viral Spike Binds to ACE2 on Uninfected Cell [Homo sapiens]
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No pathways have been reviewed or authored by Spike Trimer Translocates to the Plasma Membrane (9769812)