Query author contributions in Reactome
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Details on Person Based on studies with the rat protein whose amino acid seque...
| Class:Id | Summation:9769777 |
|---|---|
| _displayName | Based on studies with the rat protein whose amino acid seque... |
| _timestamp | 2022-04-06 14:18:49 |
| created | [InstanceEdit:9769776] Orlic-Milacic, Marija, 2022-03-22 |
| literatureReference | [LiteratureReference:9769139] Multiple sequences orchestrate subcellular trafficking of neuronal PAS domain-containing protein 4 (NPAS4) [LiteratureReference:9769391] Npas4, a novel helix-loop-helix PAS domain protein, is regulated in response to cerebral ischemia [LiteratureReference:9769227] MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors |
| modified | [InstanceEdit:9770527] Orlic-Milacic, Marija, 2022-04-06 |
| text | Based on studies with the rat protein whose amino acid sequence is 93% identical to the human protein, NPAS4 possesses an overlapping nuclear localization signal (NLS) and a nuclear export signal (NES) in its basic-helix-loop-helix (bHLH) domain, two putative NLSs and one NES in its PAS-2 domain, and two active NESs that overlap with a putative NLS in its C-terminus (Greb-Markiewicz et al. 2018). NPAS4 mainly localizes to the nucleus, but a small portion is also present in the cytoplasm and intracellular membranes (Shamloo et al. 2006, Sullivan et al. 2016). Cytoplasmic export of NPAS4 is dependent on XPO1 (Exportin-1) (Greb-Markiewicz et al. 2018). |
| (summation) | [BlackBoxEvent:9769141] NPAS4 translocates to the cytosol [Homo sapiens] |
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