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Details on Person SMPD1 converts sphingomyelin to ceramide

Class:Id	Reaction:9769742
_displayName	SMPD1 converts sphingomyelin to ceramide
_doRelease	TRUE
_timestamp	2026-01-27 16:16:52
authored	[InstanceEdit:9769736] Shamovsky, Veronica, 2022-03-22
catalystActivity	[CatalystActivity:9769744] sphingomyelin phosphodiesterase activity of SMPD1 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9769736] Shamovsky, Veronica, 2022-03-22
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
input	[SimpleEntity:29356] H2O [cytosol] [Complex:9931707] tissue factor : SPHM d18:1 [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9936123] D'Eustachio, Peter, 2025-01-20
isChimeric	FALSE
literatureReference	[LiteratureReference:9822564] Acid sphingomyelinase plays a critical role in LPS- and cytokine-induced tissue factor procoagulant activity [LiteratureReference:9671229] Sphingomyelin encrypts tissue factor: ATP-induced activation of A-SMase leads to tissue factor decryption and microvesicle shedding
modified	[InstanceEdit:9820668] Shamovsky, Veronica, 2022-11-18 [InstanceEdit:9822561] Shamovsky, Veronica, 2022-12-25 [InstanceEdit:9931706] Shamovsky, Veronica, 2024-12-12 [InstanceEdit:9935187] Shamovsky, Veronica, 2025-01-13 [InstanceEdit:9938592] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938668] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938844] Shamovsky, Veronica, 2025-02-20 [InstanceEdit:9979535] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980353] Shamovsky, Veronica, 2026-01-27
name	SMPD1 converts sphingomyelin to ceramide Sphingomyelin phosphodiesterase 1 hydrolyses sphingomyelin to ceramide
output	[SimpleEntity:1610735] ChoP [plasma membrane] [SimpleEntity:9822560] N-acylsphingosine [plasma membrane] [EntityWithAccessionedSequence:140762] sequestered tissue factor [plasma membrane] [Homo sapiens]
releaseDate	2026-03-25
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9769753] R-HSA-9769742.1
structureModified	[InstanceEdit:9931706] Shamovsky, Veronica, 2024-12-12
summation	[Summation:9820669] Sphingomyelin (SPHM), a phospholipid located in the outer le...
(hasEvent)	[Pathway:9769739] Regulation of clotting cascade [Homo sapiens]
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No pathways have been reviewed or authored by SMPD1 converts sphingomyelin to ceramide (9769742)