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Details on Person factor V -> factor Va intermediate + factor V activation peptide (FXa catalyst)

Class:Id	Reaction:9769737
_displayName	factor V -> factor Va intermediate + factor V activation peptide (FXa catalyst)
_doRelease	TRUE
_timestamp	2026-01-27 16:18:32
authored	[InstanceEdit:9769736] Shamovsky, Veronica, 2022-03-22
catalystActivity	[CatalystActivity:140768] serine-type endopeptidase activity of factor Xa [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9769736] Shamovsky, Veronica, 2022-03-22
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
input	[EntityWithAccessionedSequence:140697] factor V [extracellular region] [Homo sapiens]
internalReviewed	[InstanceEdit:9936123] D'Eustachio, Peter, 2025-01-20
literatureReference	[LiteratureReference:9930552] Activation of human factor V by factor Xa and thrombin [LiteratureReference:140680] The factor V activation paradox [LiteratureReference:9822569] Cleavage requirements for activation of factor V by factor Xa [LiteratureReference:9929742] Factor Xa activation of factor V is of paramount importance in initiating the coagulation system: lessons from a tick salivary protein [LiteratureReference:9930786] Novel insights into the regulation of coagulation by factor V isoforms, tissue factor pathway inhibitorα, and protein S
modified	[InstanceEdit:9822568] Shamovsky, Veronica, 2022-12-25 [InstanceEdit:9824043] Shamovsky, Veronica, 2023-01-13 [InstanceEdit:9929085] Shamovsky, Veronica, 2024-11-20 [InstanceEdit:9929796] Shamovsky, Veronica, 2024-11-28 [InstanceEdit:9930807] Shamovsky, Veronica, 2024-12-06 [InstanceEdit:9938611] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938671] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938847] Shamovsky, Veronica, 2025-02-20 [InstanceEdit:9979546] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980355] Shamovsky, Veronica, 2026-01-27
name	factor V -> factor Va intermediate + factor V activation peptide (FXa catalyst)
output	[Complex:9930795] factor Va intermediate [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9930787] factor V (738-1046) [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa [Homo sapiens] [Reaction:9929060] TF:FVII:FXa ->TF:FVIIa:FXa (FXa catalyst) [Homo sapiens] [Reaction:9822514] TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst) [Homo sapiens]
regulatedBy	[NegativeRegulation:9824042] Negative regulation by 'FXa:SERPINC1:HS [plasma membrane]'
releaseDate	2026-03-25
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9769748] R-HSA-9769737.1
structureModified	[InstanceEdit:9930807] Shamovsky, Veronica, 2024-12-06
summation	[Summation:9769738] This Reactome event describes proteolysis of factor V (FV (2...
(hasEvent)	[Pathway:9769735] Initiation of coagulation cascade [Homo sapiens]
(precedingEvent)	[Reaction:9930792] factor Va intermediate -> factor Va [Homo sapiens] [Reaction:9931628] TFPIα + FV intermediate + PROS1 => TFPIα:FV intermediate:PROS1 [Homo sapiens] [Reaction:9933742] factor Va intermediate + factor Xa -> factor Va intermediate:factor Xa [Homo sapiens]
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No pathways have been reviewed or authored by factor V -> factor Va intermediate + factor V activation peptide (FXa catalyst) (9769737)