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Details on Person Binding of murine agonist-activated glucocorticoid receptor ...

Class:Id	Summation:9769716
_displayName	Binding of murine agonist-activated glucocorticoid receptor ...
_timestamp	2022-03-21 23:48:12
created	[InstanceEdit:9769715] Orlic-Milacic, Marija, 2022-03-21
literatureReference	[LiteratureReference:9769348] Transcriptional suppression of the neuronal PAS domain 4 (Npas4) gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter [LiteratureReference:9769356] Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: possible involvement of a brain-specific transcription factor Npas4
text	Binding of murine agonist-activated glucocorticoid receptor Nr3c1 (also known as GR) to evolutionarily conserved glucocorticoid response elements (GREs) upstream of the Npas4 gene transcription start site represses Npas4 gene transcription (Furukawa-Hibi et al. 2012). Chronic restraint stress as well as corticosterone injection reduce Npas4 gene expression in mouse hippocampus (Yun et al. 2010).
(summation)	[BlackBoxEvent:9769713] Activated glucocorticoid receptor represses Npas4 gene transcription [Mus musculus]
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No pathways have been reviewed or authored by Binding of murine agonist-activated glucocorticoid receptor ... (9769716)