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Details on Person Based on studies in mouse, SRF (Serum response factor) binds...

Class:IdSummation:9769673
_displayNameBased on studies in mouse, SRF (Serum response factor) binds...
_timestamp2022-03-21 19:13:18
created[InstanceEdit:9769676] Orlic-Milacic, Marija, 2022-03-21
literatureReference[LiteratureReference:9768824] Adult Deletion of SRF Increases Epileptogenesis and Decreases Activity-Induced Gene Expression
[LiteratureReference:9769672] Persistent increased DNA-binding and expression of serum response factor occur with epilepsy-associated long-term plasticity changes
[LiteratureReference:9769675] Expression of activating transcription factor-2, serum response factor and cAMP/Ca response element binding protein in the adult rat brain following generalized seizures, nerve fibre lesion and ultraviolet irradiation
textBased on studies in mouse, SRF (Serum response factor) binds to the promoter region of the NPAS4 gene upon neuronal excitation (Kuzniewska et al. 2016), when Srf accumulation and phosphorylation are observed (Morris et al. 1999, Herdegen et al. 1997). Two SRF binding sites are highly conserved between human and mouse NPAS4 gene promoters (Kuzniewska et al. 2016).
(summation)[Reaction:9768832] SRF binds NPAS4 gene promoter [Homo sapiens]
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