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Details on Person miR-224 was shown to downregulate expression from the NPAS4 ...

Class:Id	Summation:9768799
_displayName	miR-224 was shown to downregulate expression from the NPAS4 ...
_timestamp	2022-04-08 17:04:22
created	[InstanceEdit:9768798] Orlic-Milacic, Marija, 2022-03-14
literatureReference	[LiteratureReference:9768769] Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs [LiteratureReference:9768785] miR-744 and miR-224 Downregulate Npas4 and Affect Lineage Differentiation Potential and Neurite Development During Neural Differentiation of Mouse Embryonic Stem Cells
modified	[InstanceEdit:9770512] Orlic-Milacic, Marija, 2022-04-05 [InstanceEdit:9770627] Orlic-Milacic, Marija, 2022-04-08
text	miR-224 was shown to downregulate expression from the NPAS4 3'UTR reporter and to downregulate human NPAS4 at both mRNA and protein levels (Bersten et al. 2014), suggesting that it forms an endonucleolytic RISC, although the existence of a non-endonucleolytic miR-224 RISC has not been excluded. Expression of mouse Npas4 is downregulated by mouse miR-224 (Choy et al. 2017).
(summation)	[BlackBoxEvent:9768782] miR-224 represses NPAS4 mRNA translation [Homo sapiens]
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