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Details on Person miR-10b binds CDH1 mRNA

Class:Id	Reaction:9768643
_displayName	miR-10b binds CDH1 mRNA
_doRelease	TRUE
_timestamp	2025-06-05 18:27:08
authored	[InstanceEdit:9768655] Orlic-Milacic, Marija, 2022-03-14
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9768655] Orlic-Milacic, Marija, 2022-03-14
edited	[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
input	[CandidateSet:9816182] miR-10b-5p RISC [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9793365] CDH1 mRNA [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimeric	FALSE
literatureReference	[LiteratureReference:9768622] MicroRNA-10b Triggers the Epithelial-Mesenchymal Transition (EMT) of Laryngeal Carcinoma Hep-2 Cells by Directly Targeting the E-cadherin [LiteratureReference:9768707] MicroRNA-10b mediates TGF-β1-regulated glioblastoma proliferation, migration and epithelial-mesenchymal transition
modified	[InstanceEdit:9768712] Orlic-Milacic, Marija, 2022-03-14 [InstanceEdit:9816194] Orlic-Milacic, Marija, 2022-09-01 [InstanceEdit:9816200] Orlic-Milacic, Marija, 2022-09-01 [InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17 [InstanceEdit:9935647] Orlic-Milacic, Marija, 2025-01-17 [InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20 [InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23 [InstanceEdit:9954118] Orlic-Milacic, Marija, 2025-06-05
name	miR-10b binds CDH1 mRNA
negativePrecedingEvent	[NegativePrecedingEvent:9954078] Negative relationship: CTBP1,CTBP2 represses CDH1 gene transcription [NegativePrecedingEvent:9954110] Negative relationship: DNTTIP1 and KDM1A repress CDH1 gene transcription [NegativePrecedingEvent:9954089] Negative relationship: PKM and TGIF2 repress CDH1 gene transcription [NegativePrecedingEvent:9954101] Negative relationship: PRC2 (EZH2) mediates repression of CDH1 gene transcription [NegativePrecedingEvent:9954105] Negative relationship: SNAI1 represses CDH1 transcription [NegativePrecedingEvent:9954061] Negative relationship: SNAI2 represses CDH1 gene transcription [NegativePrecedingEvent:9954102] Negative relationship: TCF12 represses CDH1 gene transcription [NegativePrecedingEvent:9954073] Negative relationship: TCF3 represses CDH1 gene transcription [NegativePrecedingEvent:9954054] Negative relationship: TWIST1 represses CDH1 gene transcription [NegativePrecedingEvent:9954067] Negative relationship: TWIST2 represses CDH1 gene transcription [NegativePrecedingEvent:9954082] Negative relationship: WT1 represses CDH1 gene transcription [NegativePrecedingEvent:9954084] Negative relationship: ZBTB33 represses CDH1 gene transcription [NegativePrecedingEvent:9954111] Negative relationship: ZEB1 represses CDH1 gene transcription [NegativePrecedingEvent:9954060] Negative relationship: ZEB2 represses CDH1 gene transcription [NegativePrecedingEvent:9954094] Negative relationship: ZNF217 represses CDH1 gene transcription
output	[Complex:9816191] miR-10b-5p RISC:CDH1 mRNA [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9766286] ARID1A and SWI/SNF complex stimulate CDH1 gene transcription [Homo sapiens] [Reaction:9766293] ARID1A binds CDH1 gene promoter [Homo sapiens] [BlackBoxEvent:9765372] FOXA2 stimulates CDH1 gene transcription [Homo sapiens] [Reaction:9765371] FOXA2 binds CDH1 gene promoter [Homo sapiens] [BlackBoxEvent:9765539] FOXJ2 stimulates CDH1 gene transcription [Homo sapiens] [Reaction:9765542] FOXJ2 binds CDH1 gene promoter [Homo sapiens] [BlackBoxEvent:9768079] FOXQ1 represses CDH1 gene transcription [Homo sapiens] [Reaction:9768082] FOXQ1 bind CDH1 gene promoter [Homo sapiens] [BlackBoxEvent:9765330] KLF4 stimulates CDH1 gene transcription [Homo sapiens] [Reaction:9765326] KLF4 binds CDH1 gene promoter [Homo sapiens] [BlackBoxEvent:9764863] KLF9 stimulates CDH1 gene transcription [Homo sapiens] [Reaction:9764866] KLF9 binds CDH1 gene promoter [Homo sapiens] [BlackBoxEvent:9768293] RB1 and TFAP2A stimulate CDH1 gene transcription [Homo sapiens] [Reaction:9768288] RB1 and TFAP2A bind CDH1 gene promoter [Homo sapiens] [BlackBoxEvent:9764800] SP1 stimulates CDH1 gene transcription [Homo sapiens] [Reaction:9764791] SP1 binds CDH1 gene promoter [Homo sapiens]
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9768663] R-HSA-9768643.2
summation	[Summation:9816199] A single miR-10b target site was computationally predicted i...
(hasEvent)	[Pathway:9764562] Regulation of CDH1 mRNA translation by microRNAs [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9768618] miR-10b inhibits CDH1 mRNA translation [Homo sapiens]
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No pathways have been reviewed or authored by miR-10b binds CDH1 mRNA (9768643)