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Details on Person miR-9 inhibits CDH1 mRNA translation

Class:Id	BlackBoxEvent:9768614
_displayName	miR-9 inhibits CDH1 mRNA translation
_doRelease	TRUE
_timestamp	2025-06-05 18:27:23
authored	[InstanceEdit:9768655] Orlic-Milacic, Marija, 2022-03-14
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9768655] Orlic-Milacic, Marija, 2022-03-14
edited	[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
input	[EntityWithAccessionedSequence:9793365] CDH1 mRNA [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimeric	FALSE
literatureReference	[LiteratureReference:9768650] MicroRNA-9 plays a role in interleukin-10-mediated expression of E-cadherin in acute myelogenous leukemia cells [LiteratureReference:9768658] Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway [LiteratureReference:9768675] c-Myc suppressed E-cadherin through miR-9 at the post-transcriptional level [LiteratureReference:9768693] miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
modified	[InstanceEdit:9768691] Orlic-Milacic, Marija, 2022-03-14 [InstanceEdit:9768703] Orlic-Milacic, Marija, 2022-03-14 [InstanceEdit:9816041] Orlic-Milacic, Marija, 2022-08-31 [InstanceEdit:9816142] Orlic-Milacic, Marija, 2022-09-01 [InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17 [InstanceEdit:9935647] Orlic-Milacic, Marija, 2025-01-17 [InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20 [InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23 [InstanceEdit:9954118] Orlic-Milacic, Marija, 2025-06-05
name	miR-9 inhibits CDH1 mRNA translation
negativePrecedingEvent	[NegativePrecedingEvent:9954070] Negative relationship: CTBP1,CTBP2 represses CDH1 gene transcription [NegativePrecedingEvent:9954086] Negative relationship: DNTTIP1 and KDM1A repress CDH1 gene transcription [NegativePrecedingEvent:9954112] Negative relationship: PKM and TGIF2 repress CDH1 gene transcription [NegativePrecedingEvent:9954062] Negative relationship: PRC2 (EZH2) mediates repression of CDH1 gene transcription [NegativePrecedingEvent:9954088] Negative relationship: SNAI1 represses CDH1 transcription [NegativePrecedingEvent:9954048] Negative relationship: SNAI2 represses CDH1 gene transcription [NegativePrecedingEvent:9954108] Negative relationship: TCF12 represses CDH1 gene transcription [NegativePrecedingEvent:9954103] Negative relationship: TCF3 represses CDH1 gene transcription [NegativePrecedingEvent:9954053] Negative relationship: TWIST1 represses CDH1 gene transcription [NegativePrecedingEvent:9954065] Negative relationship: TWIST2 represses CDH1 gene transcription [NegativePrecedingEvent:9954064] Negative relationship: WT1 represses CDH1 gene transcription [NegativePrecedingEvent:9954100] Negative relationship: ZBTB33 represses CDH1 gene transcription [NegativePrecedingEvent:9954075] Negative relationship: ZEB1 represses CDH1 gene transcription [NegativePrecedingEvent:9954077] Negative relationship: ZEB2 represses CDH1 gene transcription [NegativePrecedingEvent:9954115] Negative relationship: ZNF217 represses CDH1 gene transcription
output	[EntityWithAccessionedSequence:9816039] CDH1(1-882) [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[Reaction:9768616] miR-9 binds CDH1 mRNA [Homo sapiens] [BlackBoxEvent:9766286] ARID1A and SWI/SNF complex stimulate CDH1 gene transcription [Homo sapiens] [BlackBoxEvent:9765372] FOXA2 stimulates CDH1 gene transcription [Homo sapiens] [BlackBoxEvent:9765539] FOXJ2 stimulates CDH1 gene transcription [Homo sapiens] [BlackBoxEvent:9768079] FOXQ1 represses CDH1 gene transcription [Homo sapiens] [BlackBoxEvent:9765330] KLF4 stimulates CDH1 gene transcription [Homo sapiens] [BlackBoxEvent:9764863] KLF9 stimulates CDH1 gene transcription [Homo sapiens] [Reaction:9816153] MYC,MYCN bind MIR9-3 gene locus [Homo sapiens] [BlackBoxEvent:9768293] RB1 and TFAP2A stimulate CDH1 gene transcription [Homo sapiens] [BlackBoxEvent:9764800] SP1 stimulates CDH1 gene transcription [Homo sapiens] [BlackBoxEvent:9766286] ARID1A and SWI/SNF complex stimulate CDH1 gene transcription [Homo sapiens] [Reaction:9766293] ARID1A binds CDH1 gene promoter [Homo sapiens] [BlackBoxEvent:9765372] FOXA2 stimulates CDH1 gene transcription [Homo sapiens] [Reaction:9765371] FOXA2 binds CDH1 gene promoter [Homo sapiens] [BlackBoxEvent:9765539] FOXJ2 stimulates CDH1 gene transcription [Homo sapiens] [Reaction:9765542] FOXJ2 binds CDH1 gene promoter [Homo sapiens] [BlackBoxEvent:9768079] FOXQ1 represses CDH1 gene transcription [Homo sapiens] [Reaction:9768082] FOXQ1 bind CDH1 gene promoter [Homo sapiens] [BlackBoxEvent:9765330] KLF4 stimulates CDH1 gene transcription [Homo sapiens] [Reaction:9765326] KLF4 binds CDH1 gene promoter [Homo sapiens] [BlackBoxEvent:9764863] KLF9 stimulates CDH1 gene transcription [Homo sapiens] [Reaction:9764866] KLF9 binds CDH1 gene promoter [Homo sapiens] [BlackBoxEvent:9768293] RB1 and TFAP2A stimulate CDH1 gene transcription [Homo sapiens] [Reaction:9768288] RB1 and TFAP2A bind CDH1 gene promoter [Homo sapiens] [BlackBoxEvent:9764800] SP1 stimulates CDH1 gene transcription [Homo sapiens] [Reaction:9764791] SP1 binds CDH1 gene promoter [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:9816038] Negative gene expression regulation by 'miR-9-5p RISC:CDH1 mRNA [cytosol]'
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9768669] R-HSA-9768614.2
summation	[Summation:9816141] Ectopic expression of miR-9 in epithelial cell lines HMLE (H...
(hasEvent)	[Pathway:9764562] Regulation of CDH1 mRNA translation by microRNAs [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9954109] Negative relationship: miR-9 inhibits CDH1 mRNA translation
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No pathways have been reviewed or authored by miR-9 inhibits CDH1 mRNA translation (9768614)