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Details on Person UniProt:Q9BYG5 PARD6B
| Class:Id | ReferenceGeneProduct:97686 |
|---|---|
| _chainChangeLog | chain:1-372 added on Fri February 6 2015 |
| _displayName | UniProt:Q9BYG5 PARD6B |
| _timestamp | 2024-11-03 19:42:31 |
| chain | chain:1-372 |
| checksum | 79B5392D72B15BDC |
| comment | FUNCTION Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.SUBUNIT Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound RHOQ/TC10. Interacts with PALS1 (By similarity). Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with PARD3B. Interacts with ECT2.INTERACTION Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.DOMAIN The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.DOMAIN The PDZ domain mediates interaction with PALS1.SIMILARITY Belongs to the PAR6 family. |
| description | recommendedName: Partitioning defective 6 homolog beta shortName: PAR-6 beta shortName: PAR-6B |
| geneName | PARD6B PAR6B |
| identifier | Q9BYG5 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell cycle Cell division Cell junction Cell membrane Cytoplasm Membrane Phosphoprotein Proteomics identification Reference proteome Tight junction |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PARD6B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000751] ENSEMBL:ENSG00000124171 PARD6B [Homo sapiens] |
| secondaryIdentifier | PAR6B_HUMAN A2A2A7 Q9Y510 |
| sequenceLength | 372 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8975248] UniProt:Q9BYG5-1 PARD6B [Homo sapiens] [ReferenceIsoform:8975249] UniProt:Q9BYG5-2 PARD6B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:418193] PARD6B [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:419973] PARD6B [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9BYG5 PARD6B (97686)
