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Details on Person UniProt:Q9NPB6 PARD6A

Class:Id	ReferenceGeneProduct:97684
_chainChangeLog	chain:1-346 added on Sat February 7 2015
_displayName	UniProt:Q9NPB6 PARD6A
_timestamp	2025-08-15 21:17:33
chain	chain:1-346
checksum	9241E0EDC3694AD4
comment	FUNCTION Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959).SUBUNIT Interacts with MAP2K5 (By similarity). Interacts with PARD3. Interacts with GTP-bound forms of CDC42, RHOQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI (By similarity). Interacts with human T-cell leukemia virus type I TAX protein. Interacts with PALS1 and CRB3. Interacts with TGFBR1; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with ECT2 ('Thr-359' phosphorylated form) and PRKCI. Interacts with DCTN1 and PCM1 (PubMed:20719959).INTERACTION Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions. Recruited to the centrosome by a microtubule and dynein-dynactin-dependent mechanism.ALTERNATIVE PRODUCTS Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.DOMAIN The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.DOMAIN The PB1 domain mediates interactions with MAP2K5.DOMAIN The PDZ domain mediates the interaction with CRB3.PTM Phosphorylated by the TGF-beta receptor.PTM Ubiquitinated by the SCF(FBXO31) complex, leading to its proteasomal degradation.SIMILARITY Belongs to the PAR6 family.
description	recommendedName: Partitioning defective 6 homolog alpha shortName: PAR-6 shortName: PAR-6 alpha shortName: PAR-6A alternativeName: PAR6C alternativeName: Tax interaction protein 40 shortName: TIP-40
geneName	PARD6A PAR6A
identifier	Q9NPB6
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Cell cycle Cell division Cell junction Cell membrane Cell projection Cytoplasm Cytoskeleton Membrane Phosphoprotein Proteomics identification Reference proteome Tight junction Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	PARD6A
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9000235] ENSEMBL:ENSG00000102981 PARD6A [Homo sapiens]
secondaryIdentifier	PAR6A_HUMAN O14911 Q9NPJ7
sequenceLength	346
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:151684] UniProt:Q9NPB6-2 PARD6A [Homo sapiens] [ReferenceIsoform:414648] UniProt:Q9NPB6-1 PARD6A [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:418187] PARD6A [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:420001] PARD6A [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2134480] PARD6A [cell junction] [Homo sapiens] [EntityWithAccessionedSequence:2134533] p-S345-PARD6A [plasma membrane] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:2134530] O-phospho-L-serine at 345
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No pathways have been reviewed or authored by UniProt:Q9NPB6 PARD6A (97684)