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Details on Person RB1 and TFAP2A stimulate CDH1 gene transcription

Class:IdBlackBoxEvent:9768293
_displayNameRB1 and TFAP2A stimulate CDH1 gene transcription
_doReleaseTRUE
_timestamp2025-05-23 13:35:54
authored[InstanceEdit:9768289] Orlic-Milacic, Marija, 2022-03-04
compartment[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created[InstanceEdit:9768289] Orlic-Milacic, Marija, 2022-03-04
edited[InstanceEdit:9930641] Orlic-Milacic, Marija, 2024-12-04
input[EntityWithAccessionedSequence:9756422] CDH1 gene [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimericFALSE
literatureReference[LiteratureReference:9768291] Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition
[LiteratureReference:9768445] Loss of AP-2alpha results in deregulation of E-cadherin and MMP-9 and an increase in tumorigenicity of colon cancer cells in vivo
[LiteratureReference:9768544] The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2
[LiteratureReference:9768560] Ectopic expression of AP-2alpha transcription factor in the lens disrupts fiber cell differentiation
[LiteratureReference:9768541] RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2
modified[InstanceEdit:9768591] Orlic-Milacic, Marija, 2022-03-11
[InstanceEdit:9794229] Orlic-Milacic, Marija, 2022-06-29
[InstanceEdit:9794245] Orlic-Milacic, Marija, 2022-06-30
[InstanceEdit:9930643] Orlic-Milacic, Marija, 2024-12-04
[InstanceEdit:9935648] Orlic-Milacic, Marija, 2025-01-17
[InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20
[InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
nameRB1 and TFAP2A stimulate CDH1 gene transcription
output[EntityWithAccessionedSequence:9793365] CDH1 mRNA [cytosol] [Homo sapiens]
precedingEvent
regulatedBy[PositiveGeneExpressionRegulation:9794241] Positive gene expression regulation by 'RB1:TFAP2A homodimer:CDH1 gene [nucleoplasm]'
releaseDate2025-06-18
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9768296] R-HSA-9768293.1
summation[Summation:9794228] Direct upregulation of the CDH1 gene transcription by the re...
(hasEvent)[Pathway:9764790] Positive Regulation of CDH1 Gene Transcription [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9768614] miR-9 inhibits CDH1 mRNA translation [Homo sapiens]
[Reaction:9768616] miR-9 binds CDH1 mRNA [Homo sapiens]
[BlackBoxEvent:9768618] miR-10b inhibits CDH1 mRNA translation [Homo sapiens]
[Reaction:9768643] miR-10b binds CDH1 mRNA [Homo sapiens]
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No pathways have been reviewed or authored by RB1 and TFAP2A stimulate CDH1 gene transcription (9768293)
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