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Details on Person ZNF217 represses CDH1 gene transcription

Class:Id	BlackBoxEvent:9768071
_displayName	ZNF217 represses CDH1 gene transcription
_doRelease	TRUE
_timestamp	2025-05-23 13:38:10
authored	[InstanceEdit:9768077] Orlic-Milacic, Marija, 2022-03-03
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9768051] Orlic-Milacic, Marija, 2022-03-03
edited	[InstanceEdit:9931115] Orlic-Milacic, Marija, 2024-12-10
input	[EntityWithAccessionedSequence:9756422] CDH1 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimeric	FALSE
literatureReference	[LiteratureReference:9768053] The multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain [LiteratureReference:9931136] Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence [LiteratureReference:9931130] The coordination between ZNF217 and LSD1 contributes to hepatocellular carcinoma progress and is negatively regulated by miR-101
modified	[InstanceEdit:9931139] Orlic-Milacic, Marija, 2024-12-10 [InstanceEdit:9931759] Orlic-Milacic, Marija, 2024-12-12 [InstanceEdit:9935648] Orlic-Milacic, Marija, 2025-01-17 [InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20 [InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
name	ZNF217 represses CDH1 gene transcription
output	[EntityWithAccessionedSequence:9793365] CDH1 mRNA [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9768067] ZNF217 binds CDH1 gene promoter [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:9931133] Negative gene expression regulation by 'KDM1A:ZNF217:CDH1 gene'
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9768073] R-HSA-9768071.1
structureModified	[InstanceEdit:9931139] Orlic-Milacic, Marija, 2024-12-10
summation	[Summation:9931129] ZNF217 directly represses CDH1 gene transcription (Cowger et...
(hasEvent)	[Pathway:9764725] Negative Regulation of CDH1 Gene Transcription [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9954081] Negative relationship: ZNF217 represses CDH1 gene transcription [NegativePrecedingEvent:9954091] Negative relationship: ZNF217 represses CDH1 gene transcription [NegativePrecedingEvent:9954094] Negative relationship: ZNF217 represses CDH1 gene transcription [NegativePrecedingEvent:9954115] Negative relationship: ZNF217 represses CDH1 gene transcription
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