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Details on Person UniProt:Q2F514 X
| Class:Id | ReferenceGeneProduct:9768039 |
|---|---|
| _displayName | UniProt:Q2F514 X |
| _timestamp | 2022-03-03 15:49:31 |
| comment | FUNCTION: Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with host factors. {ECO:0000256|RuleBase:RU361181}. FUNCTION: Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC). Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation. This host complex would otherwise bind to viral episomal DNA, and prevents its transcription. Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT. {ECO:0000256|HAMAP-Rule:MF_04074}. SUBUNIT: May form homodimer. May interact with host CEBPA, CFLAR, CREB1, DDB1, E4F1, HBXIP, HSPD1/HSP60, NFKBIA, POLR2E and SMAD4. Interacts with host SMC5-SMC6 complex and induces its degradation. {ECO:0000256|HAMAP-Rule:MF_04074}. SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04074}. Host nucleus {ECO:0000256|HAMAP-Rule:MF_04074}. Host mitochondrion {ECO:0000256|HAMAP-Rule:MF_04074}. Note=Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes. {ECO:0000256|HAMAP- Rule:MF_04074}. PTM: A fraction may be phosphorylated in insect cells and HepG2 cells, a human hepatoblastoma cell line. Phosphorylated in vitro by host protein kinase C or mitogen-activated protein kinase. N-acetylated in insect cells. {ECO:0000256|HAMAP-Rule:MF_04074}. |
| created | [InstanceEdit:9768040] Rothfels, Karen, 2022-03-03 |
| geneName | X x |
| identifier | Q2F514 |
| keyword | Activation of host NF-kappa-B by virus Activator Apoptosis Host cytoplasm Host G2/M cell cycle arrest by virus Host mitochondrion Host nucleus Host-virus interaction Modulation of host cell cycle by virus Transcription Transcription regulation |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | Q2F514_HBV |
| species | [Species:5229092] Hepatitis B virus |
| (referenceEntity) | [EntityWithAccessionedSequence:9761890] X [cytosol] [Hepatitis B virus] |
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No pathways have been reviewed or authored by UniProt:Q2F514 X (9768039)
