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Details on Person Factor H binds to C3b

Class:Id	Reaction:976768
_displayName	Factor H binds to C3b
_doRelease	TRUE
_timestamp	2012-03-01 11:23:15
authored	[InstanceEdit:981647] Jupe, S, 2010-10-26
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:976791] Jupe, S, 2010-10-13
edited	[InstanceEdit:983442] Jupe, S, 2010-11-01
input	[EntityWithAccessionedSequence:976788] CFH [extracellular region] [Homo sapiens] [Complex:166832] C3b [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:976767] Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution [LiteratureReference:976751] Control of the amplification convertase of complement by the plasma protein beta1H
modified	[InstanceEdit:981705] Jupe, S, 2010-10-26 [InstanceEdit:998152] Jupe, S, 2010-11-09 [InstanceEdit:1096479] Jupe, S, 2010-11-30 [InstanceEdit:1168688] Jupe, S, 2011-01-06 [InstanceEdit:2109565] Jupe, S, 2012-02-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Factor H binds to C3b
output	[Complex:976755] CFH:C3b [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:166817] Cleavage of C3 by C3 convertases [Homo sapiens] [Reaction:166795] Formation of Classical C3 convertase (C4b:C2a complex) [Homo sapiens] [Reaction:173754] Properdin stabilizes C3b:Bb bound to cell surfaces [Homo sapiens] [Reaction:174551] Formation of alternative pathway C5 convertase [Homo sapiens]
releaseDate	2012-03-13
reviewed	[InstanceEdit:2109568] Bradley, DT, 2012-02-13 [InstanceEdit:2109566] Fraczek, LA, 2012-02-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2158142] R-HSA-976768.2
summation	[Summation:976812] Factor H (CFH) regulates the alternative pathway C3 converta...
(hasEvent)	[Pathway:977606] Regulation of Complement cascade [Homo sapiens]
(inferredFrom)	[Reaction:2132261] Complement factor H binds to C3b [Gallus gallus]
(normalReaction)	[FailedReaction:5260217] CFH variant decreases CFH binding to C3b [Homo sapiens]
(precedingEvent)	[Reaction:976810] Complement factor I binds to extracellular Factor H:C3b [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783478] Update Tracker - [Reaction:976768] Factor H binds to C3b - v56:[modifyText]
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