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Details on Person UniProt:Q3I5F7-2 ACOT6
| Class:Id | ReferenceIsoform:9767254 |
|---|---|
| _chainChangeLog | chain:1-421 for 9767254 added on Fri February 25 2022 |
| _displayName | UniProt:Q3I5F7-2 ACOT6 |
| _timestamp | 2026-02-20 21:36:47 |
| chain | chain:1-421 |
| checksum | CDEC8B80CAEF6F63 |
| comment | FUNCTION Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Catalyzes the hydrolysis of phytanoyl-CoA and pristanoyl-CoA, two methyl-branched fatty acids derived from phytol, that enter the body via the diet.CATALYTIC ACTIVITY pristanoyl-CoA + H2O = 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)CATALYTIC ACTIVITY phytanoyl-CoA + H2O = 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)PATHWAY Lipid metabolism; fatty acid metabolism.SUBCELLULAR LOCATION Localization to the peroxisome is uncertain since the potential C-terminal peroxisome targeting signal found in the mouse ortholog is not perfectly conserved.SUBCELLULAR LOCATION Recombinant N-terminally GFP-tagged protein localizes to the cytosol.ALTERNATIVE PRODUCTS Belongs to the C/M/P thioester hydrolase family. |
| created | [InstanceEdit:9767224] Weiser, Joel |
| description | recommendedName: fullName evidence="4"Acyl-coenzyme A thioesterase 6 shortName evidence="4"Acyl-CoA thioesterase 6 ecNumber evidence="2"3.1.2.- |
| geneName | ACOT6 C14orf42 |
| identifier | Q3I5F7 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cytoplasm Hydrolase Peroxisome Proteomics identification Reference proteome Serine esterase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ACOT6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995829] ENSEMBL:ENSG00000205669 ACOT6 [Homo sapiens] |
| secondaryIdentifier | ACOT6_HUMAN A0A2R8Y7H3 |
| sequenceLength | 421 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q3I5F7-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q3I5F7-2 ACOT6 (9767254)
