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Details on Person SUCCA binds PHD2,3:LIMD1, AJUBA, WTIP:VHL:EloB:EloC:CUL2:RBX1

Class:Id	Reaction:9767129
_displayName	SUCCA binds PHD2,3:LIMD1, AJUBA, WTIP:VHL:EloB:EloC:CUL2:RBX1
_timestamp	2022-02-24 22:03:25
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9767130] Rothfels, Karen, 2022-02-24
input	[SimpleEntity:29434] SUCCA [cytosol] [Complex:8932458] PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9763328] Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase [LiteratureReference:9763394] Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations [LiteratureReference:9763362] Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF [LiteratureReference:9763373] Hypoxia/pseudohypoxia-mediated activation of hypoxia-inducible factor-1α in cancer [LiteratureReference:9762972] Succinate is an inflammatory signal that induces IL-1β through HIF-1α
name	SUCCA binds PHD2,3:LIMD1, AJUBA, WTIP:VHL:EloB:EloC:CUL2:RBX1
output	[Complex:9767128] SUCCA: PHD2,3:LIMD1, AJUBA, WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9767127] SUCCA is transported to the cytosol [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9767132] R-HSA-9767129.1
summation	[Summation:9767114] Succinate binds to cytosolic prolyl hydroxylases (PHD, also ...
(hasEvent)	[Pathway:9767142] NFE2L2 HIF1alpha metabolic reprogramming COV2 [Homo sapiens]
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No pathways have been reviewed or authored by SUCCA binds PHD2,3:LIMD1, AJUBA, WTIP:VHL:EloB:EloC:CUL2:RBX1 (9767129)