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Details on Person Itaconate binds SDH

Class:Id	Reaction:9767119
_displayName	Itaconate binds SDH
_timestamp	2022-02-24 22:03:12
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9767120] Rothfels, Karen, 2022-02-24
input	[SimpleEntity:9767106] itaconate [mitochondrial matrix] [Complex:70990] SDH complex [mitochondrial inner membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9762914] Itaconic acid is a mammalian metabolite induced during macrophage activation [LiteratureReference:9762884] Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production [LiteratureReference:9762916] Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization [LiteratureReference:9762859] Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells [LiteratureReference:9762850] A guide to immunometabolism for immunologists [LiteratureReference:9762886] Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy [LiteratureReference:9762972] Succinate is an inflammatory signal that induces IL-1β through HIF-1α [LiteratureReference:9763321] The Glyoxylate Shunt, 60 Years On [LiteratureReference:9763316] The inhibitory effects of itaconic acid in vitro and in vivo [LiteratureReference:9763372] Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels [LiteratureReference:9762897] Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation [LiteratureReference:9763352] Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
name	Itaconate binds SDH
output	[Complex:9767122] SDH complex:itaconate [mitochondrial inner membrane] [Homo sapiens]
precedingEvent	[Reaction:9767116] ACOD1 decarboxylates cis-aconitate to itaconate [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9767124] R-HSA-9767119.1
summation	[Summation:9767121] Itaconate is synthesized in macrophages and other cells in r...
(hasEvent)	[Pathway:9767142] NFE2L2 HIF1alpha metabolic reprogramming COV2 [Homo sapiens]
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No pathways have been reviewed or authored by Itaconate binds SDH (9767119)