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Details on Person ACOD1 decarboxylates cis-aconitate to itaconate

Class:Id	Reaction:9767116
_displayName	ACOD1 decarboxylates cis-aconitate to itaconate
_timestamp	2022-02-24 22:03:06
catalystActivity	[CatalystActivity:9767112] aconitate decarboxylase activity of IRG1 [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9767115] Rothfels, Karen, 2022-02-24
input	[SimpleEntity:9767109] cis-aconitate [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
isChimeric	FALSE
literatureReference	[LiteratureReference:9762884] Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production [LiteratureReference:9762864] Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species [LiteratureReference:9762914] Itaconic acid is a mammalian metabolite induced during macrophage activation [LiteratureReference:9762938] Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription [LiteratureReference:9762972] Succinate is an inflammatory signal that induces IL-1β through HIF-1α [LiteratureReference:9762850] A guide to immunometabolism for immunologists [LiteratureReference:9762916] Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization [LiteratureReference:9762859] Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells [LiteratureReference:9762897] Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation [LiteratureReference:9762924] Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming [LiteratureReference:9762886] Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy
name	ACOD1 decarboxylates cis-aconitate to itaconate
output	[SimpleEntity:9767106] itaconate [mitochondrial matrix] [SimpleEntity:29376] CO2 [mitochondrial matrix]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9767118] R-HSA-9767116.1
summation	[Summation:9767117] Cis-aconitate decarboxylase I (ACOD1) catalyzes the conversi...
(hasEvent)	[Pathway:9767142] NFE2L2 HIF1alpha metabolic reprogramming COV2 [Homo sapiens]
(precedingEvent)	[Reaction:9767119] Itaconate binds SDH [Homo sapiens]
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No pathways have been reviewed or authored by ACOD1 decarboxylates cis-aconitate to itaconate (9767116)