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Details on Person MAP1LC3B binds KEAP1 and SQSTM1

Class:IdReaction:9766677
_displayNameMAP1LC3B binds KEAP1 and SQSTM1
_doReleaseTRUE
_timestamp2022-02-28 16:32:34
authored[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
compartment[Compartment:70101] cytosol
created[InstanceEdit:9766676] Rothfels, Karen, 2022-02-23
edited[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
input[Complex:9766649] SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:5205651] MAP1LC3B [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9759060] p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
[LiteratureReference:9758982] Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination
[LiteratureReference:9759058] p62 links autophagy and Nrf2 signaling
[LiteratureReference:9766515] Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage
[LiteratureReference:9766507] Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1
modified[InstanceEdit:9767018] Rothfels, Karen, 2022-02-24
[InstanceEdit:9767541] Rothfels, Karen, 2022-02-28
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMAP1LC3B binds KEAP1 and SQSTM1
output[Complex:9766679] MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2022-03-23
reviewed[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9766680] R-HSA-9766677.2
summation[Summation:9766678] SQSTM1 targets ubiquitinated cargo such as KEAP1 for degrada...
(hasEvent)[Pathway:9755511] KEAP1-NFE2L2 pathway [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9766656] RBX1:CUL3 dissociates from forming autophagosome [Homo sapiens]
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No pathways have been reviewed or authored by MAP1LC3B binds KEAP1 and SQSTM1 (9766677)