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Details on Person RBX1:CUL3 dissociates from forming autophagosome

Class:Id	BlackBoxEvent:9766656
_displayName	RBX1:CUL3 dissociates from forming autophagosome
_doRelease	TRUE
_timestamp	2022-02-28 16:33:38
authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9766658] Rothfels, Karen, 2022-02-23
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
input	[Complex:9766679] MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9766641] Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway [LiteratureReference:9759063] p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription [LiteratureReference:9766636] Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy [LiteratureReference:9766631] Keap1 degradation by autophagy for the maintenance of redox homeostasis
modified	[InstanceEdit:9766696] Rothfels, Karen, 2022-02-23 [InstanceEdit:9767050] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767159] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767216] Rothfels, Karen, 2022-02-25 [InstanceEdit:9767541] Rothfels, Karen, 2022-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RBX1:CUL3 dissociates from forming autophagosome
output	[Complex:9766659] MAP1LC3B:SESN1,2:ub K420 p-S349 SQSTM1 oligomer:ub-KEAP1 [cytosol] [Homo sapiens] [Complex:9766655] NEDD8-CUL3:RBX1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9766677] MAP1LC3B binds KEAP1 and SQSTM1 [Homo sapiens] [Reaction:9766645] CUL3:RBX1 ubiquitinates KEAP1 [Homo sapiens]
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9766662] R-HSA-9766656.2
summation	[Summation:9766657] KEAP1 is a substrate for SQSTM1-mediated autophagy (Zhang et...
(hasEvent)	[Pathway:9755511] KEAP1-NFE2L2 pathway [Homo sapiens]
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No pathways have been reviewed or authored by RBX1:CUL3 dissociates from forming autophagosome (9766656)