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Details on Person CUL3:RBX1 ubiquitinates KEAP1

Class:IdReaction:9766645
_displayNameCUL3:RBX1 ubiquitinates KEAP1
_doReleaseTRUE
_timestamp2022-02-28 16:32:19
authored[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
catalystActivity[CatalystActivity:9766646] ubiquitin protein ligase activity of SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9766650] Rothfels, Karen, 2022-02-23
edited[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
input[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[Complex:9766685] SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9766641] Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway
[LiteratureReference:9766631] Keap1 degradation by autophagy for the maintenance of redox homeostasis
modified[InstanceEdit:9766690] Rothfels, Karen, 2022-02-23
[InstanceEdit:9766709] Rothfels, Karen, 2022-02-23
[InstanceEdit:9767012] Rothfels, Karen, 2022-02-24
[InstanceEdit:9767541] Rothfels, Karen, 2022-02-28
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameCUL3:RBX1 ubiquitinates KEAP1
output[Complex:9766649] SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2022-03-23
reviewed[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9766653] R-HSA-9766645.2
summation[Summation:9766643] KEAP1 is ubiquitinated by the CUL3:RBX1 complex in an SQSTM1...
(hasEvent)[Pathway:9755511] KEAP1-NFE2L2 pathway [Homo sapiens]
(precedingEvent)[Reaction:9766677] MAP1LC3B binds KEAP1 and SQSTM1 [Homo sapiens]
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No pathways have been reviewed or authored by CUL3:RBX1 ubiquitinates KEAP1 (9766645)